Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB_PD Exclusive	FUMA_PD_GWAS	4.36e-02	3.55e-02	6.84e-02	4.97e-05
FUMA_PD_GWAS Exclusive	UKB_PD	4.15e-01	2.83e-01	3.31e-02	5.30e-01
UKB_PD Exclusive	FUMA_PD_GWAS Exclusive	1.76e-02	2.56e-02	1.10e-01	1.04e-04
FUMA_PD_GWAS Exclusive	UKB_PD Exclusive	7.85e-01	4.40e-01	1.50e-01	7.35e-01
UKB_PD Exclusive	Overlap	8.72e-01	8.62e-01	9.46e-01	7.79e-01
FUMA_PD_GWAS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	1.48e-03
Overlap	Exclusives	8.89e-02	1.19e-04	7.84e-02	6.87e-08



Evaluating how well UKB_PD genes are linked to FUMA_PD_GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_PD Exclusive	FUMA_PD_GWAS	0.60	2.12	2.60	1.53	4.75
FUMA_PD_GWAS Exclusive	UKB_PD	0.53	1.80	1.24	1.68	0.77
UKB_PD Exclusive	FUMA_PD_GWAS Exclusive	0.60	2.08	2.81	1.71	4.58
FUMA_PD_GWAS Exclusive	UKB_PD Exclusive	0.52	1.13	0.48	0.88	0.51
UKB_PD Exclusive	Overlap	0.35	0.01	-0.41	-0.21	-0.73
FUMA_PD_GWAS Exclusive	Overlap	1.00	5.00	2.84	3.76	2.16
Overlap	Exclusives	0.63	2.54	4.92	3.06	6.45

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_PD Exclusive	FUMA_PD_GWAS	0.01	1.52	2.07	0.99	2.96
FUMA_PD_GWAS Exclusive	UKB_PD	0.01	11.58	12.60	14.96	3.56
UKB_PD Exclusive	FUMA_PD_GWAS Exclusive	0.01	1.58	2.72	1.21	3.49
FUMA_PD_GWAS Exclusive	UKB_PD Exclusive	0.01	6.58	3.79	3.68	1.06
UKB_PD Exclusive	Overlap	0.00	-0.26	-0.12	-0.17	-0.39
FUMA_PD_GWAS Exclusive	Overlap	0.04	1075.92	204.00	573.17	39.44
Overlap	Exclusives	0.03	8.43	21.44	9.88	19.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB_PD Exclusive	72	70	;KDM5D
FUMA_PD_GWAS Exclusive	156	151	FAM47E-STBD1;LSM 7.00;HLA-DRB6;MIR4697;LINC02210-CRHR1
Overlap	3	2	undefined