Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB_PD Exclusive	Singleton	4.96e-02	1.03e-01	7.83e-02	4.75e-01
Singleton Exclusive	UKB_PD	2.83e-03	3.73e-02	8.95e-04	1.30e-01
UKB_PD Exclusive	Singleton Exclusive	2.16e-02	8.45e-02	3.95e-02	4.66e-01
Singleton Exclusive	UKB_PD Exclusive	1.55e-03	3.92e-02	2.26e-04	9.26e-02
UKB_PD Exclusive	Overlap	4.75e-01	9.70e-01	4.16e-01	7.72e-01
Singleton Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	4.89e-03	6.58e-03	1.40e-11	1.48e-03



Evaluating how well UKB_PD genes are linked to Singleton genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_PD Exclusive	Singleton	0.58	-1.94	-2.47	-1.58	1.32
Singleton Exclusive	UKB_PD	0.47	-1.73	-1.57	-0.90	-0.84
UKB_PD Exclusive	Singleton Exclusive	0.58	-2.28	-2.00	-1.78	1.28
Singleton Exclusive	UKB_PD Exclusive	0.46	-2.04	-1.87	-0.87	-1.29
UKB_PD Exclusive	Overlap	0.60	-0.76	-0.13	-0.82	0.43
Singleton Exclusive	Overlap	1.00	2.47	1.95	1.99	1.82
Overlap	Exclusives	0.58	3.15	1.65	1.91	2.56

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_PD Exclusive	Singleton	0.00	-0.71	-1.04	-0.57	0.63
Singleton Exclusive	UKB_PD	0.00	0.39	0.04	0.91	1.17
UKB_PD Exclusive	Singleton Exclusive	0.00	-0.83	-0.87	-0.48	0.17
Singleton Exclusive	UKB_PD Exclusive	0.00	-0.85	-0.51	-0.34	-0.83
UKB_PD Exclusive	Overlap	0.00	-0.61	-0.55	-0.59	-0.12
Singleton Exclusive	Overlap	0.06	477.64	463.62	195.35	380.83
Overlap	Exclusives	0.01	10.09	10.14	6.51	2.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB_PD Exclusive	74	73	KDM5D
Singleton Exclusive	19	19	
Overlap	2	1