Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
ADC splice 28 Exclusive	ad gwas	8.82e-01	5.86e-01	8.54e-01	2.42e-01
ad gwas Exclusive	ADC splice 28	4.66e-01	2.78e-01	5.22e-02	7.64e-02
ADC splice 28 Exclusive	ad gwas Exclusive	9.74e-01	9.74e-01	8.31e-01	2.62e-01
ad gwas Exclusive	ADC splice 28 Exclusive	2.64e-01	4.55e-01	1.10e-01	1.19e-01
ADC splice 28 Exclusive	Overlap	2.31e-01	1.31e-01	5.62e-01	9.43e-01
ad gwas Exclusive	Overlap	1.83e-09	2.30e-07	1.83e-09	1.83e-09
Overlap	Exclusives	4.66e-02	1.88e-01	1.36e-14	7.94e-03



Evaluating how well ADC splice 28 genes are linked to ad gwas genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC splice 28 Exclusive	ad gwas	0.60	-0.27	-1.16	-0.52	1.69
ad gwas Exclusive	ADC splice 28	0.55	0.34	1.20	1.09	2.28
ADC splice 28 Exclusive	ad gwas Exclusive	0.61	0.18	-0.17	-0.05	1.65
ad gwas Exclusive	ADC splice 28 Exclusive	0.54	-0.19	0.93	0.44	1.78
ADC splice 28 Exclusive	Overlap	0.54	-2.29	-3.26	-1.59	0.33
ad gwas Exclusive	Overlap	1.00	3.30	2.87	3.33	3.17
Overlap	Exclusives	0.59	1.69	2.51	2.07	3.11

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
ADC splice 28 Exclusive	ad gwas	0.00	-0.53	-1.22	-0.53	0.48
ad gwas Exclusive	ADC splice 28	0.01	1.97	3.10	2.88	3.88
ADC splice 28 Exclusive	ad gwas Exclusive	0.00	-0.16	-0.56	-0.24	0.47
ad gwas Exclusive	ADC splice 28 Exclusive	0.01	-0.55	0.47	-0.13	0.45
ADC splice 28 Exclusive	Overlap	0.00	-0.92	-1.39	-0.87	-0.23
ad gwas Exclusive	Overlap	0.06	181.29	64.20	258.44	187.17
Overlap	Exclusives	0.04	40.66	43.66	30.40	30.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
ADC splice 28 Exclusive	135	134	MFRP
ad gwas Exclusive	21	21	
Overlap	4	4