Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UKB_PD	2019_PD_GWAS	1.35e-01	1.29e-01	1.78e-01	7.52e-04
2019_PD_GWAS	UKB_PD	6.93e-01	6.91e-01	4.00e-02	7.05e-01



Evaluating how well UKB_PD genes are linked to 2019_PD_GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_PD	2019_PD_GWAS	0.63	2.06	2.24	1.68	3.87
2019_PD_GWAS	UKB_PD	0.52	1.26	0.48	1.24	0.64

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UKB_PD	2019_PD_GWAS	0.01	2.21	2.43	1.82	1.78
2019_PD_GWAS	UKB_PD	0.01	1.03	3.10	3.11	2.35

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UKB_PD	76	74	;KDM5D
2019_PD_GWAS	97	90	LOC100131289;GBAP1;FAM47E-STBD1;GS1-124K5.11;MAPT-AS1;CASC16;LINC00693