Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) UKB_PD Exclusive Botas 2.22e-01 5.10e-01 5.60e-01 2.66e-02 Botas Exclusive UKB_PD 9.33e-02 7.17e-01 3.76e-08 9.45e-01 UKB_PD Exclusive Botas Exclusive 5.22e-01 7.35e-01 8.34e-01 2.99e-02 Botas Exclusive UKB_PD Exclusive 6.24e-02 5.70e-01 6.66e-09 7.01e-01 UKB_PD Exclusive Overlap 5.35e-01 8.71e-01 4.95e-01 7.33e-01 Botas Exclusive Overlap 1.98e-02 1.98e-02 1.98e-02 1.98e-02 Overlap Exclusives 5.99e-02 2.45e-01 1.42e-10 1.29e-01 Evaluating how well UKB_PD genes are linked to Botas genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) UKB_PD Exclusive Botas 0.70 -0.83 0.09 -0.15 2.72 Botas Exclusive UKB_PD 0.49 -0.82 -1.00 -0.22 -0.22 UKB_PD Exclusive Botas Exclusive 0.71 -0.42 0.01 0.09 2.39 Botas Exclusive UKB_PD Exclusive 0.48 -1.07 -1.24 -0.43 -0.57 UKB_PD Exclusive Overlap 0.60 -0.66 -0.08 -0.71 0.42 Botas Exclusive Overlap 1.00 2.49 2.00 1.90 2.01 Overlap Exclusives 0.54 1.33 0.05 0.89 1.17 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) UKB_PD Exclusive Botas 0.00 -0.61 -0.74 -0.30 1.56 Botas Exclusive UKB_PD 0.00 1.39 0.14 0.88 0.38 UKB_PD Exclusive Botas Exclusive 0.00 -0.46 -0.86 -0.20 0.70 Botas Exclusive UKB_PD Exclusive 0.00 -0.19 -0.23 -0.29 -0.26 UKB_PD Exclusive Overlap 0.00 -0.35 -0.52 -0.53 -0.24 Botas Exclusive Overlap 0.02 87.81 273.17 62.76 132.72 Overlap Exclusives 0.01 5.22 3.20 2.75 2.58 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes UKB_PD Exclusive 75 73 ;KDM5D Botas Exclusive 11 10 Parkin Overlap 1 1