Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_2_5_253 Exclusive	ad_gs_25	1.52e-03	1.75e-03	6.63e-04	8.67e-06
ad_gs_25 Exclusive	1000run1_2_5_253	1.17e-01	2.13e-01	7.76e-03	1.98e-03
1000run1_2_5_253 Exclusive	ad_gs_25 Exclusive	2.43e-03	1.33e-03	5.71e-04	8.05e-05
ad_gs_25 Exclusive	1000run1_2_5_253 Exclusive	7.02e-02	1.92e-01	2.12e-03	7.73e-03
1000run1_2_5_253 Exclusive	Overlap	5.39e-01	7.89e-01	3.98e-01	9.71e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	8.99e-02	3.50e-02	5.03e-26	5.41e-04



Evaluating how well 1000run1_2_5_253 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_5_253 Exclusive	ad_gs_25	0.77	2.85	3.58	1.69	4.87
ad_gs_25 Exclusive	1000run1_2_5_253	0.55	0.72	1.33	0.96	2.82
1000run1_2_5_253 Exclusive	ad_gs_25 Exclusive	0.75	2.34	3.25	1.86	4.36
ad_gs_25 Exclusive	1000run1_2_5_253 Exclusive	0.55	0.40	1.40	0.92	2.58
1000run1_2_5_253 Exclusive	Overlap	0.88	1.76	1.26	1.68	2.38
ad_gs_25 Exclusive	Overlap	1.00	2.94	2.50	2.62	2.94
Overlap	Exclusives	0.58	3.53	3.29	2.33	4.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_5_253 Exclusive	ad_gs_25	0.00	3.30	3.20	1.51	4.26
ad_gs_25 Exclusive	1000run1_2_5_253	0.02	1.79	3.51	2.48	3.59
1000run1_2_5_253 Exclusive	ad_gs_25 Exclusive	0.00	3.06	3.50	1.99	4.34
ad_gs_25 Exclusive	1000run1_2_5_253 Exclusive	0.02	0.28	1.98	1.15	2.81
1000run1_2_5_253 Exclusive	Overlap	0.00	1.08	1.25	3.20	3.25
ad_gs_25 Exclusive	Overlap	0.03	96.30	68.12	124.48	82.41
Overlap	Exclusives	0.03	19.42	15.24	11.69	15.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_2_5_253 Exclusive	250	250	
ad_gs_25 Exclusive	22	22	
Overlap	3	3