Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_2_7_210 Exclusive	ad_gs_25	2.79e-04	9.23e-04	1.59e-04	7.95e-06
ad_gs_25 Exclusive	1000run1_2_7_210	3.81e-01	3.37e-02	2.33e-04	2.70e-04
1000run1_2_7_210 Exclusive	ad_gs_25 Exclusive	6.26e-04	1.38e-03	3.34e-04	6.82e-05
ad_gs_25 Exclusive	1000run1_2_7_210 Exclusive	1.32e-01	4.50e-02	1.00e-03	8.46e-04
1000run1_2_7_210 Exclusive	Overlap	3.82e-01	7.89e-01	2.96e-01	6.03e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	5.34e-02	2.20e-02	6.54e-25	4.38e-04



Evaluating how well 1000run1_2_7_210 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_7_210 Exclusive	ad_gs_25	0.78	3.32	3.25	2.22	5.37
ad_gs_25 Exclusive	1000run1_2_7_210	0.57	1.21	2.42	1.77	3.11
1000run1_2_7_210 Exclusive	ad_gs_25 Exclusive	0.77	2.68	3.30	2.16	4.28
ad_gs_25 Exclusive	1000run1_2_7_210 Exclusive	0.56	0.91	2.05	1.38	2.98
1000run1_2_7_210 Exclusive	Overlap	0.87	1.81	1.09	1.47	2.35
ad_gs_25 Exclusive	Overlap	1.00	3.13	2.30	3.24	2.87
Overlap	Exclusives	0.59	3.07	3.30	1.69	4.20

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_7_210 Exclusive	ad_gs_25	0.01	8.86	6.85	4.58	6.33
ad_gs_25 Exclusive	1000run1_2_7_210	0.02	3.07	5.54	4.19	3.98
1000run1_2_7_210 Exclusive	ad_gs_25 Exclusive	0.00	6.79	5.55	4.66	6.91
ad_gs_25 Exclusive	1000run1_2_7_210 Exclusive	0.01	0.71	2.95	1.80	3.28
1000run1_2_7_210 Exclusive	Overlap	0.00	1.75	2.43	1.96	7.66
ad_gs_25 Exclusive	Overlap	0.03	83.64	74.91	186.75	95.61
Overlap	Exclusives	0.03	25.13	22.15	12.48	21.12

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_2_7_210 Exclusive	207	207	
ad_gs_25 Exclusive	22	22	
Overlap	3	3