Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_2_8_168 Exclusive	ad_gs_25	3.64e-04	1.03e-03	1.38e-04	6.39e-06
ad_gs_25 Exclusive	1000run1_2_8_168	7.35e-01	2.88e-02	3.10e-03	4.13e-04
1000run1_2_8_168 Exclusive	ad_gs_25 Exclusive	8.04e-04	8.63e-04	2.11e-04	2.41e-04
ad_gs_25 Exclusive	1000run1_2_8_168 Exclusive	5.11e-01	3.63e-02	2.12e-03	1.05e-03
1000run1_2_8_168 Exclusive	Overlap	2.61e-01	6.76e-01	2.16e-01	4.78e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	3.82e-02	1.38e-02	9.94e-18	2.51e-04



Evaluating how well 1000run1_2_8_168 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_8_168 Exclusive	ad_gs_25	0.79	3.21	4.53	2.44	5.08
ad_gs_25 Exclusive	1000run1_2_8_168	0.58	1.48	2.46	1.56	3.28
1000run1_2_8_168 Exclusive	ad_gs_25 Exclusive	0.78	2.64	4.12	2.26	4.28
ad_gs_25 Exclusive	1000run1_2_8_168 Exclusive	0.57	1.00	2.55	1.57	2.87
1000run1_2_8_168 Exclusive	Overlap	0.89	2.10	1.39	1.82	2.06
ad_gs_25 Exclusive	Overlap	1.00	2.87	2.24	2.82	3.13
Overlap	Exclusives	0.60	2.67	3.39	1.92	4.69

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_8_168 Exclusive	ad_gs_25	0.00	4.99	5.89	4.22	3.06
ad_gs_25 Exclusive	1000run1_2_8_168	0.01	3.05	5.04	3.31	4.65
1000run1_2_8_168 Exclusive	ad_gs_25 Exclusive	0.00	4.34	4.67	3.30	0.26
ad_gs_25 Exclusive	1000run1_2_8_168 Exclusive	0.01	1.76	3.53	1.66	3.10
1000run1_2_8_168 Exclusive	Overlap	0.00	0.95	1.88	1.85	4.44
ad_gs_25 Exclusive	Overlap	0.03	62.77	58.42	123.63	159.53
Overlap	Exclusives	0.03	24.14	22.78	12.67	28.79

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_2_8_168 Exclusive	165	165	
ad_gs_25 Exclusive	22	22	
Overlap	3	3