Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_2_9_141 Exclusive	ad_gs_25	5.86e-06	4.48e-04	3.71e-05	7.39e-07
ad_gs_25 Exclusive	1000run1_2_9_141	6.08e-01	1.75e-02	3.00e-03	2.48e-03
1000run1_2_9_141 Exclusive	ad_gs_25 Exclusive	6.14e-05	2.10e-03	1.16e-04	2.23e-05
ad_gs_25 Exclusive	1000run1_2_9_141 Exclusive	8.17e-01	2.46e-02	9.13e-03	4.03e-03
1000run1_2_9_141 Exclusive	Overlap	1.00e-01	2.04e-01	9.38e-02	1.57e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.49e-02	2.69e-03	4.85e-16	3.33e-04



Evaluating how well 1000run1_2_9_141 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_9_141 Exclusive	ad_gs_25	0.81	4.13	4.40	2.68	6.56
ad_gs_25 Exclusive	1000run1_2_9_141	0.57	1.51	2.73	2.14	3.02
1000run1_2_9_141 Exclusive	ad_gs_25 Exclusive	0.80	3.21	4.32	3.23	4.32
ad_gs_25 Exclusive	1000run1_2_9_141 Exclusive	0.57	1.31	2.28	1.66	2.49
1000run1_2_9_141 Exclusive	Overlap	0.92	2.93	1.93	2.03	2.60
ad_gs_25 Exclusive	Overlap	1.00	2.73	2.24	2.63	3.45
Overlap	Exclusives	0.60	2.85	3.54	1.76	4.79

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_9_141 Exclusive	ad_gs_25	0.01	10.16	6.24	3.24	14.52
ad_gs_25 Exclusive	1000run1_2_9_141	0.01	3.89	8.55	5.46	7.35
1000run1_2_9_141 Exclusive	ad_gs_25 Exclusive	0.00	6.21	5.45	7.86	8.36
ad_gs_25 Exclusive	1000run1_2_9_141 Exclusive	0.01	2.11	4.98	1.86	3.31
1000run1_2_9_141 Exclusive	Overlap	0.00	2.33	3.56	2.63	4.67
ad_gs_25 Exclusive	Overlap	0.03	105.36	52.92	143.76	64.27
Overlap	Exclusives	0.03	28.20	31.51	20.47	15.97

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_2_9_141 Exclusive	138	138	
ad_gs_25 Exclusive	22	22	
Overlap	3	3