Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_3_125 Exclusive	ad_gs_25	3.49e-01	8.70e-01	3.65e-01	1.08e-01
ad_gs_25 Exclusive	1000run1_3_125	8.39e-01	3.36e-02	5.90e-03	2.80e-03
1000run1_3_125 Exclusive	ad_gs_25 Exclusive	4.22e-01	7.37e-01	6.01e-01	1.52e-01
ad_gs_25 Exclusive	1000run1_3_125 Exclusive	6.11e-01	4.25e-02	1.83e-02	9.64e-03
1000run1_3_125 Exclusive	Overlap	2.68e-01	9.01e-01	2.48e-01	1.36e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.44e-02	2.23e-03	3.00e-15	7.57e-04



Evaluating how well 1000run1_3_125 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_125 Exclusive	ad_gs_25	0.63	0.51	0.25	0.22	2.46
ad_gs_25 Exclusive	1000run1_3_125	0.57	1.23	2.19	1.44	2.92
1000run1_3_125 Exclusive	ad_gs_25 Exclusive	0.61	0.60	-0.11	0.01	1.91
ad_gs_25 Exclusive	1000run1_3_125 Exclusive	0.56	0.62	2.00	1.01	2.18
1000run1_3_125 Exclusive	Overlap	0.77	1.34	0.13	0.82	1.73
ad_gs_25 Exclusive	Overlap	1.00	2.70	2.42	3.21	3.13
Overlap	Exclusives	0.60	3.55	3.29	1.66	4.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_125 Exclusive	ad_gs_25	0.00	0.35	-0.30	-0.04	0.26
ad_gs_25 Exclusive	1000run1_3_125	0.01	1.48	2.85	1.97	3.03
1000run1_3_125 Exclusive	ad_gs_25 Exclusive	0.00	0.37	-0.58	-0.32	0.03
ad_gs_25 Exclusive	1000run1_3_125 Exclusive	0.01	-0.27	1.25	-0.04	0.35
1000run1_3_125 Exclusive	Overlap	0.00	0.54	0.54	1.20	0.01
ad_gs_25 Exclusive	Overlap	0.03	124.38	57.68	175.52	153.18
Overlap	Exclusives	0.02	22.21	24.63	11.01	14.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_3_125 Exclusive	122	122	
ad_gs_25 Exclusive	22	22	
Overlap	3	3