Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_3_1_113 Exclusive	ad_gs_25	1.53e-01	6.27e-01	2.93e-01	5.50e-02
ad_gs_25 Exclusive	1000run1_3_1_113	5.66e-01	1.42e-02	2.25e-03	4.77e-03
1000run1_3_1_113 Exclusive	ad_gs_25 Exclusive	3.17e-01	6.87e-01	6.73e-01	6.85e-02
ad_gs_25 Exclusive	1000run1_3_1_113 Exclusive	5.25e-01	3.95e-02	3.41e-03	7.40e-03
1000run1_3_1_113 Exclusive	Overlap	2.48e-01	8.66e-01	2.75e-01	1.32e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	9.17e-03	1.85e-03	7.20e-14	1.25e-03



Evaluating how well 1000run1_3_1_113 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_1_113 Exclusive	ad_gs_25	0.62	0.65	-0.06	0.08	2.49
ad_gs_25 Exclusive	1000run1_3_1_113	0.56	0.76	2.08	1.47	2.11
1000run1_3_1_113 Exclusive	ad_gs_25 Exclusive	0.60	0.41	-0.09	-0.18	1.86
ad_gs_25 Exclusive	1000run1_3_1_113 Exclusive	0.55	0.50	1.63	1.11	1.69
1000run1_3_1_113 Exclusive	Overlap	0.77	1.14	0.50	0.73	1.63
ad_gs_25 Exclusive	Overlap	1.00	2.90	2.25	2.64	2.90
Overlap	Exclusives	0.60	2.65	4.06	2.23	3.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_1_113 Exclusive	ad_gs_25	0.00	0.51	-0.26	-0.10	0.50
ad_gs_25 Exclusive	1000run1_3_1_113	0.01	0.90	3.38	1.63	2.54
1000run1_3_1_113 Exclusive	ad_gs_25 Exclusive	0.00	0.13	-0.51	-0.34	0.98
ad_gs_25 Exclusive	1000run1_3_1_113 Exclusive	0.01	-0.33	1.04	-0.02	0.47
1000run1_3_1_113 Exclusive	Overlap	0.00	1.12	0.86	1.28	1.78
ad_gs_25 Exclusive	Overlap	0.03	131.98	62.70	73.10	0.86
Overlap	Exclusives	0.02	20.81	32.68	20.91	16.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_3_1_113 Exclusive	110	110	
ad_gs_25 Exclusive	22	22	
Overlap	3	3