Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_3_2_97 Exclusive	ad_gs_25	1.92e-01	4.58e-01	3.94e-01	1.46e-01
ad_gs_25 Exclusive	1000run1_3_2_97	6.78e-01	2.84e-02	6.21e-03	6.98e-03
1000run1_3_2_97 Exclusive	ad_gs_25 Exclusive	3.74e-01	5.65e-01	5.93e-01	4.19e-01
ad_gs_25 Exclusive	1000run1_3_2_97 Exclusive	6.91e-01	3.58e-02	5.77e-03	1.40e-02
1000run1_3_2_97 Exclusive	Overlap	2.04e-01	7.49e-01	2.61e-01	2.16e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	7.13e-03	1.32e-03	1.26e-14	1.78e-04



Evaluating how well 1000run1_3_2_97 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_2_97 Exclusive	ad_gs_25	0.63	0.49	0.10	0.20	2.12
ad_gs_25 Exclusive	1000run1_3_2_97	0.56	1.34	2.23	1.34	2.29
1000run1_3_2_97 Exclusive	ad_gs_25 Exclusive	0.61	0.44	0.07	-0.12	1.53
ad_gs_25 Exclusive	1000run1_3_2_97 Exclusive	0.55	0.84	1.95	1.29	1.58
1000run1_3_2_97 Exclusive	Overlap	0.77	0.90	0.30	0.72	1.64
ad_gs_25 Exclusive	Overlap	1.00	3.07	2.22	2.58	2.82
Overlap	Exclusives	0.61	3.34	4.62	2.29	4.78

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_2_97 Exclusive	ad_gs_25	0.00	0.37	-0.14	0.04	0.93
ad_gs_25 Exclusive	1000run1_3_2_97	0.01	2.00	4.16	1.02	1.27
1000run1_3_2_97 Exclusive	ad_gs_25 Exclusive	0.00	0.32	-0.24	-0.22	0.28
ad_gs_25 Exclusive	1000run1_3_2_97 Exclusive	0.01	-0.19	1.14	-0.05	0.08
1000run1_3_2_97 Exclusive	Overlap	0.00	0.71	0.35	0.68	0.08
ad_gs_25 Exclusive	Overlap	0.03	93.09	65.42	89.65	49.68
Overlap	Exclusives	0.03	28.44	35.68	21.30	33.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_3_2_97 Exclusive	94	94	
ad_gs_25 Exclusive	22	22	
Overlap	3	3