Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_3_3_84 Exclusive	ad_gs_25	1.38e-01	5.30e-01	3.02e-01	9.56e-02
ad_gs_25 Exclusive	1000run1_3_3_84	8.04e-01	2.40e-02	2.51e-03	3.16e-03
1000run1_3_3_84 Exclusive	ad_gs_25 Exclusive	2.94e-01	5.65e-01	4.47e-01	2.12e-01
ad_gs_25 Exclusive	1000run1_3_3_84 Exclusive	7.54e-01	3.18e-02	9.40e-03	8.36e-03
1000run1_3_3_84 Exclusive	Overlap	3.65e-01	6.85e-01	3.65e-01	3.04e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	6.72e-03	5.14e-04	2.40e-15	5.03e-05



Evaluating how well 1000run1_3_3_84 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_3_84 Exclusive	ad_gs_25	0.63	0.67	0.09	0.09	2.04
ad_gs_25 Exclusive	1000run1_3_3_84	0.58	1.59	2.78	1.72	2.54
1000run1_3_3_84 Exclusive	ad_gs_25 Exclusive	0.61	0.34	0.06	0.12	1.79
ad_gs_25 Exclusive	1000run1_3_3_84 Exclusive	0.56	1.05	2.01	1.37	2.00
1000run1_3_3_84 Exclusive	Overlap	0.76	0.87	0.53	0.68	1.37
ad_gs_25 Exclusive	Overlap	1.00	3.13	2.24	2.91	2.73
Overlap	Exclusives	0.63	3.96	4.86	2.55	4.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_3_84 Exclusive	ad_gs_25	0.00	0.62	0.31	0.02	1.16
ad_gs_25 Exclusive	1000run1_3_3_84	0.01	1.67	4.52	1.24	2.70
1000run1_3_3_84 Exclusive	ad_gs_25 Exclusive	0.00	0.26	0.03	0.05	0.76
ad_gs_25 Exclusive	1000run1_3_3_84 Exclusive	0.00	-0.06	1.16	0.07	0.56
1000run1_3_3_84 Exclusive	Overlap	0.00	0.13	0.29	0.17	-0.04
ad_gs_25 Exclusive	Overlap	0.03	77.23	55.39	161.23	68.55
Overlap	Exclusives	0.03	30.48	39.13	9.31	31.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_3_3_84 Exclusive	81	81	
ad_gs_25 Exclusive	22	22	
Overlap	3	3