Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_3_5_68 Exclusive	ad_gs_25	6.06e-02	3.12e-01	3.73e-01	9.94e-02
ad_gs_25 Exclusive	1000run1_3_5_68	5.95e-01	3.04e-02	1.80e-02	6.89e-03
1000run1_3_5_68 Exclusive	ad_gs_25 Exclusive	1.93e-01	4.63e-01	4.31e-01	3.83e-01
ad_gs_25 Exclusive	1000run1_3_5_68 Exclusive	8.72e-01	4.09e-02	2.68e-02	1.58e-02
1000run1_3_5_68 Exclusive	Overlap	3.04e-01	9.22e-01	5.03e-01	2.82e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	4.33e-03	4.20e-04	3.31e-14	3.39e-05



Evaluating how well 1000run1_3_5_68 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_5_68 Exclusive	ad_gs_25	0.61	0.70	-0.07	-0.13	2.29
ad_gs_25 Exclusive	1000run1_3_5_68	0.58	1.47	2.34	1.76	2.90
1000run1_3_5_68 Exclusive	ad_gs_25 Exclusive	0.59	0.44	-0.28	-0.18	1.45
ad_gs_25 Exclusive	1000run1_3_5_68 Exclusive	0.56	0.89	2.14	1.35	1.77
1000run1_3_5_68 Exclusive	Overlap	0.74	0.73	0.17	0.50	1.36
ad_gs_25 Exclusive	Overlap	1.00	3.06	2.34	2.87	2.97
Overlap	Exclusives	0.64	4.43	4.68	2.40	4.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_3_5_68 Exclusive	ad_gs_25	0.00	0.50	0.43	-0.11	1.47
ad_gs_25 Exclusive	1000run1_3_5_68	0.01	2.56	4.74	3.19	1.32
1000run1_3_5_68 Exclusive	ad_gs_25 Exclusive	0.00	0.51	0.09	-0.06	-0.05
ad_gs_25 Exclusive	1000run1_3_5_68 Exclusive	0.00	-0.14	1.57	-0.01	0.32
1000run1_3_5_68 Exclusive	Overlap	0.00	0.41	-0.07	0.36	0.08
ad_gs_25 Exclusive	Overlap	0.03	94.01	72.81	114.11	94.04
Overlap	Exclusives	0.03	34.94	44.90	30.71	38.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_3_5_68 Exclusive	65	65	
ad_gs_25 Exclusive	22	22	
Overlap	3	3