Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_2_839 Exclusive	ad_gs_25	1.35e-02	2.12e-02	2.95e-04	1.12e-05
ad_gs_25 Exclusive	1000run1_2_839	3.29e-02	2.69e-02	3.04e-09	9.34e-08
1000run1_2_839 Exclusive	ad_gs_25 Exclusive	3.67e-02	2.82e-02	7.10e-04	7.41e-05
ad_gs_25 Exclusive	1000run1_2_839 Exclusive	2.76e-02	4.16e-02	5.19e-08	1.09e-07
1000run1_2_839 Exclusive	Overlap	9.15e-01	7.89e-01	7.76e-01	1.27e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	1.59e-01	4.38e-02	3.67e-72	1.60e-08



Evaluating how well 1000run1_2_839 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_839 Exclusive	ad_gs_25	0.78	3.11	3.46	2.66	4.91
ad_gs_25 Exclusive	1000run1_2_839	0.55	2.02	2.36	2.03	4.98
1000run1_2_839 Exclusive	ad_gs_25 Exclusive	0.77	2.30	3.38	2.11	4.26
ad_gs_25 Exclusive	1000run1_2_839 Exclusive	0.55	1.76	2.19	1.65	4.90
1000run1_2_839 Exclusive	Overlap	0.84	0.88	0.58	1.24	1.89
ad_gs_25 Exclusive	Overlap	1.00	3.19	2.08	2.77	3.37
Overlap	Exclusives	0.56	2.02	3.24	1.51	6.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_839 Exclusive	ad_gs_25	0.00	3.72	5.86	4.12	10.63
ad_gs_25 Exclusive	1000run1_2_839	0.05	2.65	2.66	3.12	5.22
1000run1_2_839 Exclusive	ad_gs_25 Exclusive	0.00	3.54	5.57	2.95	2.58
ad_gs_25 Exclusive	1000run1_2_839 Exclusive	0.05	1.62	2.18	2.06	4.37
1000run1_2_839 Exclusive	Overlap	0.00	1.16	3.58	2.51	7.29
ad_gs_25 Exclusive	Overlap	0.03	121.29	51.47	129.64	74.88
Overlap	Exclusives	0.06	6.77	7.54	4.14	8.88

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_2_839 Exclusive	835	833	PTGES3L-AARSD1;STON1-GTF2A1L
ad_gs_25 Exclusive	22	22	
Overlap	3	3