Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_2_4_375 Exclusive	ad_gs_25	1.18e-03	4.11e-04	1.08e-04	3.07e-06
ad_gs_25 Exclusive	1000run1_2_4_375	2.75e-01	7.92e-02	6.95e-05	6.47e-04
1000run1_2_4_375 Exclusive	ad_gs_25 Exclusive	1.96e-03	1.77e-04	1.29e-04	6.19e-06
ad_gs_25 Exclusive	1000run1_2_4_375 Exclusive	3.89e-01	1.27e-01	1.53e-04	1.03e-03
1000run1_2_4_375 Exclusive	Overlap	5.48e-01	5.94e-01	2.82e-01	2.49e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	2.00e-01	1.54e-01	9.01e-43	5.03e-05



Evaluating how well 1000run1_2_4_375 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_4_375 Exclusive	ad_gs_25	0.81	3.33	5.13	2.97	5.06
ad_gs_25 Exclusive	1000run1_2_4_375	0.56	1.50	2.14	1.77	4.12
1000run1_2_4_375 Exclusive	ad_gs_25 Exclusive	0.80	2.61	3.98	2.72	4.97
ad_gs_25 Exclusive	1000run1_2_4_375 Exclusive	0.56	1.62	1.86	1.67	3.69
1000run1_2_4_375 Exclusive	Overlap	0.87	1.59	1.12	1.95	2.44
ad_gs_25 Exclusive	Overlap	1.00	3.10	2.60	2.83	2.82
Overlap	Exclusives	0.57	2.11	2.13	1.47	4.63

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_4_375 Exclusive	ad_gs_25	0.01	5.31	5.33	5.15	3.16
ad_gs_25 Exclusive	1000run1_2_4_375	0.03	2.74	4.10	3.50	4.78
1000run1_2_4_375 Exclusive	ad_gs_25 Exclusive	0.00	4.86	6.41	5.12	5.95
ad_gs_25 Exclusive	1000run1_2_4_375 Exclusive	0.02	2.13	2.72	2.67	3.43
1000run1_2_4_375 Exclusive	Overlap	0.00	0.69	9.20	2.79	0.39
ad_gs_25 Exclusive	Overlap	0.03	107.52	83.74	102.51	65.00
Overlap	Exclusives	0.03	15.40	12.61	6.73	12.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_2_4_375 Exclusive	372	371	PTGES3L-AARSD1
ad_gs_25 Exclusive	22	22	
Overlap	3	3