Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_2_2_570 Exclusive	ad_gs_25	3.33e-04	4.48e-04	3.84e-06	1.50e-07
ad_gs_25 Exclusive	1000run1_2_2_570	1.77e-01	1.36e-02	6.33e-08	1.74e-08
1000run1_2_2_570 Exclusive	ad_gs_25 Exclusive	5.92e-04	4.26e-04	8.01e-06	1.07e-06
ad_gs_25 Exclusive	1000run1_2_2_570 Exclusive	2.48e-01	1.37e-02	6.93e-08	8.15e-08
1000run1_2_2_570 Exclusive	Overlap	5.30e-01	7.58e-01	2.54e-01	2.82e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.40e-01	3.56e-02	4.01e-55	8.21e-09



Evaluating how well 1000run1_2_2_570 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_2_570 Exclusive	ad_gs_25	0.83	4.56	4.98	3.95	5.30
ad_gs_25 Exclusive	1000run1_2_2_570	0.57	2.69	2.93	2.59	5.89
1000run1_2_2_570 Exclusive	ad_gs_25 Exclusive	0.82	4.31	5.13	3.18	5.46
ad_gs_25 Exclusive	1000run1_2_2_570 Exclusive	0.57	2.87	2.94	2.47	5.49
1000run1_2_2_570 Exclusive	Overlap	0.88	1.84	1.14	1.88	2.55
ad_gs_25 Exclusive	Overlap	1.00	2.60	2.40	2.75	2.91
Overlap	Exclusives	0.57	2.11	3.43	1.95	7.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_2_2_570 Exclusive	ad_gs_25	0.01	8.01	10.04	8.06	1.20
ad_gs_25 Exclusive	1000run1_2_2_570	0.04	4.25	5.44	4.63	7.86
1000run1_2_2_570 Exclusive	ad_gs_25 Exclusive	0.01	8.39	12.99	5.85	6.83
ad_gs_25 Exclusive	1000run1_2_2_570 Exclusive	0.04	3.74	4.57	3.86	5.76
1000run1_2_2_570 Exclusive	Overlap	0.00	1.43	8.87	2.53	2.24
ad_gs_25 Exclusive	Overlap	0.03	63.91	80.82	119.80	99.16
Overlap	Exclusives	0.05	10.23	12.13	7.22	13.45

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_2_2_570 Exclusive	567	565	PTGES3L-AARSD1;STON1-GTF2A1L
ad_gs_25 Exclusive	22	22	
Overlap	3	3