Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_1_5_2094 Exclusive	ad_gs_25	1.87e-01	2.04e-01	1.63e-02	7.08e-04
ad_gs_25 Exclusive	1000run1_1_5_2094	8.04e-06	4.38e-02	7.62e-17	1.33e-11
1000run1_1_5_2094 Exclusive	ad_gs_25 Exclusive	3.20e-01	3.65e-01	6.33e-02	1.28e-02
ad_gs_25 Exclusive	1000run1_1_5_2094 Exclusive	3.68e-06	3.11e-02	1.38e-11	2.18e-11
1000run1_1_5_2094 Exclusive	Overlap	8.50e-01	5.62e-01	1.84e-01	4.78e-03
ad_gs_25 Exclusive	Overlap	7.45e-12	7.45e-12	4.47e-11	4.17e-10
Overlap	Exclusives	4.24e-03	5.12e-03	1.22e-179	2.99e-13



Evaluating how well 1000run1_1_5_2094 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_1_5_2094 Exclusive	ad_gs_25	0.74	2.10	2.47	1.88	3.90
ad_gs_25 Exclusive	1000run1_1_5_2094	0.55	1.38	2.71	1.35	8.35
1000run1_1_5_2094 Exclusive	ad_gs_25 Exclusive	0.71	1.73	2.52	1.92	3.07
ad_gs_25 Exclusive	1000run1_1_5_2094 Exclusive	0.54	1.07	2.58	1.15	7.33
1000run1_1_5_2094 Exclusive	Overlap	0.86	0.63	0.08	1.03	2.67
ad_gs_25 Exclusive	Overlap	1.00	3.71	2.73	3.33	4.60
Overlap	Exclusives	0.55	2.44	3.26	1.12	9.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_1_5_2094 Exclusive	ad_gs_25	0.00	2.01	2.98	2.17	6.81
ad_gs_25 Exclusive	1000run1_1_5_2094	0.12	1.75	3.18	1.95	6.28
1000run1_1_5_2094 Exclusive	ad_gs_25 Exclusive	0.00	2.02	3.35	2.57	1.95
ad_gs_25 Exclusive	1000run1_1_5_2094 Exclusive	0.12	1.10	2.23	1.42	5.61
1000run1_1_5_2094 Exclusive	Overlap	0.00	0.37	0.76	1.18	7.17
ad_gs_25 Exclusive	Overlap	0.06	154.32	94.58	116.72	188.07
Overlap	Exclusives	0.12	3.91	4.30	2.10	8.36

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_1_5_2094 Exclusive	2085	2074	C3orf49;UGT2A1;PRAMEF11;C19orf84;FAM47E-STBD1;PTGES3L-AARSD1;CROCC2;RBAK-RBAKDN;STON1-GTF2A1L;MFRP;RPL17-C18orf32
ad_gs_25 Exclusive	20	20	
Overlap	5	5