Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
1000run1_0_5_8708 Exclusive	ad_gs_25	8.82e-02	5.83e-01	1.74e-02	3.78e-05
ad_gs_25 Exclusive	1000run1_0_5_8708	2.60e-07	1.26e-09	1.96e-294	1.86e-101
1000run1_0_5_8708 Exclusive	ad_gs_25 Exclusive	3.47e-01	5.10e-01	9.68e-02	1.27e-02
ad_gs_25 Exclusive	1000run1_0_5_8708 Exclusive	3.04e-09	2.88e-09	5.87e-247	1.77e-100
1000run1_0_5_8708 Exclusive	Overlap	9.39e-02	7.47e-01	1.05e-01	3.81e-03
ad_gs_25 Exclusive	Overlap	4.77e-10	1.95e-11	1.83e-11	1.23e-10
Overlap	Exclusives	2.77e-39	5.27e-10	8.84e-241	5.00e-100



Evaluating how well 1000run1_0_5_8708 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_0_5_8708 Exclusive	ad_gs_25	0.76	7.46	2.38	10.17	4.49
ad_gs_25 Exclusive	1000run1_0_5_8708	0.57	2.42	29.65	1.71	54.38
1000run1_0_5_8708 Exclusive	ad_gs_25 Exclusive	0.76	6.38	2.06	7.74	2.90
ad_gs_25 Exclusive	1000run1_0_5_8708 Exclusive	0.57	2.13	19.79	1.44	42.00
1000run1_0_5_8708 Exclusive	Overlap	0.75	6.26	1.46	11.06	3.49
ad_gs_25 Exclusive	Overlap	0.96	4.35	7.59	4.06	6.45
Overlap	Exclusives	0.57	2.24	21.32	1.92	53.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
1000run1_0_5_8708 Exclusive	ad_gs_25	0.01	18.29	4.53	20.20	3.44
ad_gs_25 Exclusive	1000run1_0_5_8708	0.49	2.54	35.80	2.08	42.50
1000run1_0_5_8708 Exclusive	ad_gs_25 Exclusive	0.00	16.41	3.62	16.39	1.42
ad_gs_25 Exclusive	1000run1_0_5_8708 Exclusive	0.49	1.87	27.77	1.59	33.55
1000run1_0_5_8708 Exclusive	Overlap	0.00	16.74	0.89	24.11	3.58
ad_gs_25 Exclusive	Overlap	0.14	234.10	619.01	307.91	388.97
Overlap	Exclusives	0.49	2.16	29.56	2.13	40.17

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
1000run1_0_5_8708 Exclusive	8674	8630	NPIPB6;RPS10-NUDT3;RFX1;EPPIN-WFDC6;CORO7-PAM16;ANKHD1-EIF4EBP3;FAM205C;MUC2;RNF103-CHMP3;ZHX1-C8orf76;CYP3A7-CYP3A51P;MFRP;CROCC2;TNFSF12-TNFSF13;PRAMEF11;TVP23C-CDRT4;STON1-GTF2A1L;SHANK3;C3orf49;FAM47E-STBD1;RBAK-RBAKDN;UGT2A1;ZNF559-ZNF177;JMJD7-PLA2G4B;GSG1L2;TUBA4B;C19orf84;RPL41;RFPL2;FXYD6-FXYD2;CCDC188;RPL17-C18orf32;PTGES3L-AARSD1;DNAJC25-GNG10;TFDP2;CCDC7;C8orf89;IQCJ-SCHIP1;MSANTD3-TMEFF1;TTC6;PRR36;MYO15B;PAK6;ABHD14A-ACY1
ad_gs_25 Exclusive	11	11	
Overlap	14	14