Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
RareEaml Exclusive	Gs_all	2.97e-05	4.97e-06	3.19e-04	1.44e-21
Gs_all Exclusive	RareEaml	8.90e-03	2.06e-02	8.07e-09	3.45e-02
RareEaml Exclusive	Gs_all Exclusive	8.12e-05	7.32e-06	8.85e-04	6.37e-21
Gs_all Exclusive	RareEaml Exclusive	2.88e-02	4.91e-02	1.15e-07	1.22e-01
RareEaml Exclusive	Overlap	2.56e-01	5.78e-01	2.33e-01	2.99e-02
Gs_all Exclusive	Overlap	7.45e-12	6.02e-07	7.45e-12	6.02e-07
Overlap	Exclusives	9.49e-06	2.37e-05	4.88e-26	2.35e-14



Evaluating how well RareEaml genes are linked to Gs_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RareEaml Exclusive	Gs_all	0.73	3.83	6.15	3.02	12.43
Gs_all Exclusive	RareEaml	0.55	6.54	4.20	3.57	2.63
RareEaml Exclusive	Gs_all Exclusive	0.73	3.88	6.84	3.10	10.88
Gs_all Exclusive	RareEaml Exclusive	0.54	5.77	3.48	3.71	1.96
RareEaml Exclusive	Overlap	0.78	1.48	1.18	1.38	2.18
Gs_all Exclusive	Overlap	0.99	3.91	4.35	3.59	3.84
Overlap	Exclusives	0.64	3.51	6.19	2.74	9.46

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RareEaml Exclusive	Gs_all	0.03	4.50	10.42	2.48	17.23
Gs_all Exclusive	RareEaml	0.02	22.79	15.99	7.82	10.22
RareEaml Exclusive	Gs_all Exclusive	0.02	4.20	9.37	2.96	15.05
Gs_all Exclusive	RareEaml Exclusive	0.01	8.06	4.59	2.79	2.27
RareEaml Exclusive	Overlap	0.00	0.26	0.01	0.25	0.36
Gs_all Exclusive	Overlap	0.11	338.00	362.38	548.26	124.25
Overlap	Exclusives	0.05	13.55	28.97	10.45	33.14

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
RareEaml Exclusive	202	198	MFRP;AC004076.1;IQANK1;AP000812.4
Gs_all Exclusive	198	175	HLA class I;HLA class II;LINC00917;SCL22A3;LINC00603;7-Mar;LINC00675;SAT2B-AS1;CDKN2B-AS1;TERC;SnoU13;METRLN;COLCA1;LINC00673; MYNN;ZMIZ1-AS1;RTELI; PIGU;LOC146513;POUF5F1B;ANRIL;SNHG15;c11orf53
Overlap	5	5