Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
RareEpi Exclusive	Gs_all	6.80e-01	9.86e-01	6.37e-01	1.18e-07
Gs_all Exclusive	RareEpi	4.34e-02	1.56e-01	3.10e-07	3.83e-02
RareEpi Exclusive	Gs_all Exclusive	8.82e-01	9.73e-01	4.18e-01	4.52e-07
Gs_all Exclusive	RareEpi Exclusive	3.66e-02	2.66e-01	2.59e-06	4.12e-02
RareEpi Exclusive	Overlap	5.92e-01	8.04e-01	5.74e-01	4.68e-01
Gs_all Exclusive	Overlap	9.85e-05	9.85e-04	9.85e-05	9.85e-04
Overlap	Exclusives	3.41e-11	4.98e-11	1.84e-31	1.10e-27



Evaluating how well RareEpi genes are linked to Gs_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RareEpi Exclusive	Gs_all	0.64	-0.56	0.66	0.05	5.96
Gs_all Exclusive	RareEpi	0.56	1.62	1.52	1.12	2.09
RareEpi Exclusive	Gs_all Exclusive	0.64	-0.30	0.72	0.12	6.92
Gs_all Exclusive	RareEpi Exclusive	0.55	1.22	1.21	1.09	2.01
RareEpi Exclusive	Overlap	0.72	0.79	0.66	1.07	1.19
Gs_all Exclusive	Overlap	0.99	3.17	2.28	2.40	2.50
Overlap	Exclusives	0.71	2.73	8.27	3.25	12.77

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RareEpi Exclusive	Gs_all	0.02	-0.46	0.81	0.00	6.79
Gs_all Exclusive	RareEpi	0.01	7.77	3.57	2.62	3.91
RareEpi Exclusive	Gs_all Exclusive	0.02	-0.33	1.01	0.14	7.77
Gs_all Exclusive	RareEpi Exclusive	0.01	1.78	0.20	-0.05	0.77
RareEpi Exclusive	Overlap	0.00	0.99	-0.15	-0.00	0.08
Gs_all Exclusive	Overlap	0.13	1357.13	561.52	813.29	15.23
Overlap	Exclusives	0.05	6.75	22.98	8.46	32.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
RareEpi Exclusive	134	131	PRAMEF15;VSIG10L2;MFRP
Gs_all Exclusive	201	178	METRLN;LINC00673;SCL22A3;7-Mar;SAT2B-AS1;TERC;LINC00917;COLCA1;HLA class I;c11orf53; PIGU;ANRIL;CDKN2B-AS1; MYNN;SNHG15;ZMIZ1-AS1;RTELI;SnoU13;POUF5F1B;HLA class II;LINC00675;LOC146513;LINC00603
Overlap	2	2