Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
RareSigma Exclusive	Gs_all	3.07e-01	5.32e-01	9.16e-03	3.26e-12
Gs_all Exclusive	RareSigma	8.38e-02	1.17e-01	7.05e-11	3.96e-03
RareSigma Exclusive	Gs_all Exclusive	3.18e-01	4.79e-01	9.15e-03	2.93e-12
Gs_all Exclusive	RareSigma Exclusive	9.83e-02	3.00e-01	5.00e-09	1.68e-02
RareSigma Exclusive	Overlap	8.60e-01	5.03e-01	9.64e-01	3.75e-01
Gs_all Exclusive	Overlap	4.43e-04	2.45e-03	2.49e-05	8.43e-04
Overlap	Exclusives	1.00e-06	4.84e-06	6.01e-24	4.51e-23



Evaluating how well RareSigma genes are linked to Gs_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RareSigma Exclusive	Gs_all	0.67	0.35	1.27	0.82	7.73
Gs_all Exclusive	RareSigma	0.56	2.73	2.84	2.93	3.32
RareSigma Exclusive	Gs_all Exclusive	0.68	0.13	1.07	0.71	8.44
Gs_all Exclusive	RareSigma Exclusive	0.55	2.58	1.98	2.02	3.04
RareSigma Exclusive	Overlap	0.61	-0.30	-0.36	-0.17	1.00
Gs_all Exclusive	Overlap	0.92	4.25	3.80	4.01	4.14
Overlap	Exclusives	0.65	4.05	6.73	3.69	11.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RareSigma Exclusive	Gs_all	0.02	0.39	2.50	0.98	14.12
Gs_all Exclusive	RareSigma	0.02	13.33	7.95	7.38	7.67
RareSigma Exclusive	Gs_all Exclusive	0.02	0.32	2.31	0.87	16.34
Gs_all Exclusive	RareSigma Exclusive	0.01	1.19	0.58	0.18	2.39
RareSigma Exclusive	Overlap	0.00	-0.69	-0.69	-0.63	-0.26
Gs_all Exclusive	Overlap	0.20	811.59	725.07	1015.14	774.81
Overlap	Exclusives	0.05	11.49	20.69	11.35	30.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
RareSigma Exclusive	245	243	MFRP;AC004076.1
Gs_all Exclusive	196	173	c11orf53;METRLN;LINC00673;LINC00917;CDKN2B-AS1;COLCA1;POUF5F1B;7-Mar; MYNN;HLA class II;ANRIL;SNHG15;RTELI; PIGU;LINC00675;LINC00603;TERC;SnoU13;SCL22A3;LOC146513;SAT2B-AS1;ZMIZ1-AS1;HLA class I
Overlap	7	7