Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
RGene Exclusive	Gs_all	2.11e-05	2.40e-03	1.81e-49	7.17e-29
Gs_all Exclusive	RGene	2.97e-09	2.61e-05	3.75e-50	9.57e-50
RGene Exclusive	Gs_all Exclusive	7.20e-04	6.05e-03	2.78e-42	1.45e-25
Gs_all Exclusive	RGene Exclusive	4.40e-06	1.07e-04	6.04e-46	8.71e-46
RGene Exclusive	Overlap	5.06e-04	7.07e-02	6.57e-12	6.41e-11
Gs_all Exclusive	Overlap	7.97e-14	1.25e-11	2.64e-26	4.43e-21
Overlap	Exclusives	1.03e-10	2.76e-10	1.56e-58	1.69e-59



Evaluating how well RGene genes are linked to Gs_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RGene Exclusive	Gs_all	0.77	4.57	5.30	4.78	13.28
Gs_all Exclusive	RGene	0.83	2.19	7.14	5.01	15.22
RGene Exclusive	Gs_all Exclusive	0.76	4.06	6.19	4.84	13.03
Gs_all Exclusive	RGene Exclusive	0.82	1.74	7.17	5.43	14.57
RGene Exclusive	Overlap	0.97	1.86	2.46	2.85	5.62
Gs_all Exclusive	Overlap	1.00	3.01	4.23	3.08	6.34
Overlap	Exclusives	0.78	2.99	9.39	4.80	20.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
RGene Exclusive	Gs_all	0.05	2.12	13.08	11.53	43.96
Gs_all Exclusive	RGene	0.07	2.17	16.33	12.66	55.35
RGene Exclusive	Gs_all Exclusive	0.04	2.17	12.08	11.59	30.61
Gs_all Exclusive	RGene Exclusive	0.04	-0.72	5.95	7.48	33.15
RGene Exclusive	Overlap	0.02	-0.55	8.62	8.46	33.37
Gs_all Exclusive	Overlap	0.22	5.68	214.08	92.76	1076.97
Overlap	Exclusives	0.08	3.36	23.34	17.29	55.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
RGene Exclusive	195	193	PES 1.00;ARL 11.00
Gs_all Exclusive	192	169	POUF5F1B;METRLN;SNHG15;SnoU13;RTELI;7-Mar;LINC00603;LINC00675;TERC;HLA class II;ANRIL; PIGU;COLCA1;SCL22A3;HLA class I;SAT2B-AS1;LINC00917;CDKN2B-AS1;LOC146513;ZMIZ1-AS1;LINC00673;c11orf53; MYNN
Overlap	11	11