Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) RareCauchy Exclusive Gs_all 9.75e-03 4.09e-04 3.16e-35 5.61e-26 Gs_all Exclusive RareCauchy 9.58e-04 5.47e-05 2.01e-25 6.72e-24 RareCauchy Exclusive Gs_all Exclusive 1.08e-02 8.24e-04 1.62e-30 7.66e-24 Gs_all Exclusive RareCauchy Exclusive 3.04e-02 3.45e-04 4.55e-23 9.42e-22 RareCauchy Exclusive Overlap 3.91e-01 3.49e-01 1.05e-05 2.49e-05 Gs_all Exclusive Overlap 1.18e-16 5.93e-12 1.18e-16 2.29e-12 Overlap Exclusives 4.67e-07 8.87e-09 4.25e-35 3.58e-38 Evaluating how well RareCauchy genes are linked to Gs_all genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) RareCauchy Exclusive Gs_all 0.77 3.06 5.99 4.84 13.48 Gs_all Exclusive RareCauchy 0.73 4.10 5.33 5.25 10.70 RareCauchy Exclusive Gs_all Exclusive 0.76 3.54 5.78 4.72 12.20 Gs_all Exclusive RareCauchy Exclusive 0.72 3.94 4.61 4.67 10.37 RareCauchy Exclusive Overlap 0.93 1.68 1.69 1.85 3.95 Gs_all Exclusive Overlap 1.00 3.23 3.72 2.75 4.69 Overlap Exclusives 0.73 3.73 7.15 3.01 16.39 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) RareCauchy Exclusive Gs_all 0.05 2.69 9.19 13.85 49.96 Gs_all Exclusive RareCauchy 0.03 4.36 10.24 12.91 19.61 RareCauchy Exclusive Gs_all Exclusive 0.05 2.35 9.96 13.24 49.40 Gs_all Exclusive RareCauchy Exclusive 0.02 -0.32 3.74 5.89 14.19 RareCauchy Exclusive Overlap 0.00 0.44 1.22 4.70 1.48 Gs_all Exclusive Overlap 0.11 89.95 202.17 167.63 100.64 Overlap Exclusives 0.05 6.63 20.43 9.28 35.99 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes RareCauchy Exclusive 156 155 MFRP Gs_all Exclusive 196 173 MYNN;SCL22A3;LINC00917;ANRIL;SAT2B-AS1;CDKN2B-AS1;SnoU13;LINC00603;RTELI;TERC;LINC00675;7-Mar;LINC00673;HLA class I;COLCA1;LOC146513;METRLN;HLA class II;POUF5F1B;SNHG15; PIGU;c11orf53;ZMIZ1-AS1 Overlap 7 7