Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UR_Eaml Exclusive	Gs_all	1.51e-01	4.54e-01	6.10e-01	3.08e-11
Gs_all Exclusive	UR_Eaml	1.52e-01	2.21e-01	4.75e-05	4.48e-01
UR_Eaml Exclusive	Gs_all Exclusive	3.11e-01	4.11e-01	7.44e-01	6.28e-11
Gs_all Exclusive	UR_Eaml Exclusive	1.07e-01	3.03e-01	5.18e-04	6.13e-01
UR_Eaml Exclusive	Overlap	9.64e-01	8.06e-01	9.99e-01	9.06e-02
Gs_all Exclusive	Overlap	4.59e-05	2.38e-02	4.59e-05	2.85e-04
Overlap	Exclusives	2.10e-03	3.61e-04	7.41e-23	1.18e-10



Evaluating how well UR_Eaml genes are linked to Gs_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Eaml Exclusive	Gs_all	0.67	1.16	0.77	0.39	7.67
Gs_all Exclusive	UR_Eaml	0.52	2.20	1.29	1.72	1.03
UR_Eaml Exclusive	Gs_all Exclusive	0.67	0.91	1.04	0.39	7.58
Gs_all Exclusive	UR_Eaml Exclusive	0.51	1.86	0.94	1.44	0.28
UR_Eaml Exclusive	Overlap	0.67	0.11	0.05	-0.01	1.82
Gs_all Exclusive	Overlap	0.84	2.15	1.97	2.47	3.23
Overlap	Exclusives	0.62	2.78	3.85	2.14	8.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Eaml Exclusive	Gs_all	0.02	3.94	5.61	2.02	16.64
Gs_all Exclusive	UR_Eaml	0.01	7.63	3.99	3.99	3.59
UR_Eaml Exclusive	Gs_all Exclusive	0.02	3.32	5.39	1.91	19.28
Gs_all Exclusive	UR_Eaml Exclusive	0.01	0.63	0.32	0.81	-0.23
UR_Eaml Exclusive	Overlap	0.00	0.06	0.72	-0.09	0.18
Gs_all Exclusive	Overlap	0.06	102.19	105.24	130.13	57.38
Overlap	Exclusives	0.04	7.28	14.55	8.69	20.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UR_Eaml Exclusive	206	204	VNN 1.00;NPIPB6
Gs_all Exclusive	195	172	LINC00917;LINC00675;METRLN; PIGU;CDKN2B-AS1; MYNN;ANRIL;POUF5F1B;LINC00673;SCL22A3;RTELI;TERC;7-Mar;LOC146513;SnoU13;ZMIZ1-AS1;SAT2B-AS1;c11orf53;COLCA1;LINC00603;SNHG15;HLA class I;HLA class II
Overlap	8	8