Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UR_Epi Exclusive	Gs_all	5.83e-02	1.03e-02	4.64e-10	3.51e-14
Gs_all Exclusive	UR_Epi	2.94e-02	1.62e-01	2.12e-06	3.02e-06
UR_Epi Exclusive	Gs_all Exclusive	1.47e-01	1.04e-02	9.84e-10	4.89e-14
Gs_all Exclusive	UR_Epi Exclusive	5.05e-02	1.43e-01	1.90e-05	1.51e-05
UR_Epi Exclusive	Overlap	4.94e-01	4.85e-01	2.49e-02	1.73e-02
Gs_all Exclusive	Overlap	7.71e-02	7.71e-02	2.82e-02	2.94e-02
Overlap	Exclusives	8.40e-04	1.30e-07	7.29e-42	1.21e-24



Evaluating how well UR_Epi genes are linked to Gs_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Epi Exclusive	Gs_all	0.70	1.22	3.77	2.00	9.53
Gs_all Exclusive	UR_Epi	0.68	1.69	2.01	2.26	5.04
UR_Epi Exclusive	Gs_all Exclusive	0.70	1.07	3.97	2.06	8.43
Gs_all Exclusive	UR_Epi Exclusive	0.67	1.61	1.71	1.99	4.68
UR_Epi Exclusive	Overlap	0.87	1.02	1.40	1.47	2.19
Gs_all Exclusive	Overlap	0.92	0.44	0.71	1.58	2.66
Overlap	Exclusives	0.73	1.47	5.49	1.85	13.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Epi Exclusive	Gs_all	0.03	2.08	7.93	5.18	21.16
Gs_all Exclusive	UR_Epi	0.02	9.50	13.71	14.54	29.73
UR_Epi Exclusive	Gs_all Exclusive	0.03	1.70	8.47	6.01	20.18
Gs_all Exclusive	UR_Epi Exclusive	0.01	0.71	1.62	2.45	7.45
UR_Epi Exclusive	Overlap	0.00	0.21	1.13	0.79	0.59
Gs_all Exclusive	Overlap	0.12	263.51	134.78	341.69	241.46
Overlap	Exclusives	0.04	5.48	23.47	7.13	32.01

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UR_Epi Exclusive	59	59	
Gs_all Exclusive	200	177	HLA class II; MYNN;7-Mar;SAT2B-AS1;SNHG15;c11orf53;LINC00603;METRLN;LINC00675;HLA class I;CDKN2B-AS1;LINC00917;POUF5F1B;RTELI; PIGU;COLCA1;SnoU13;ZMIZ1-AS1;LINC00673;LOC146513;ANRIL;TERC;SCL22A3
Overlap	3	3