Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UR_Sigma Exclusive	Gs_all	8.32e-01	9.02e-01	8.24e-01	6.53e-10
Gs_all Exclusive	UR_Sigma	2.56e-01	2.49e-01	9.76e-03	1.84e-01
UR_Sigma Exclusive	Gs_all Exclusive	7.66e-01	8.40e-01	8.90e-01	2.50e-08
Gs_all Exclusive	UR_Sigma Exclusive	2.64e-01	2.38e-01	1.52e-02	3.06e-01
UR_Sigma Exclusive	Overlap	8.56e-01	2.82e-01	9.48e-01	2.62e-02
Gs_all Exclusive	Overlap	8.41e-03	8.41e-03	7.77e-03	5.58e-03
Overlap	Exclusives	6.07e-02	2.01e-04	9.23e-39	4.70e-15



Evaluating how well UR_Sigma genes are linked to Gs_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Sigma Exclusive	Gs_all	0.64	-0.02	0.08	-0.18	6.45
Gs_all Exclusive	UR_Sigma	0.52	1.01	0.48	1.01	0.78
UR_Sigma Exclusive	Gs_all Exclusive	0.64	0.21	-0.14	0.13	5.44
Gs_all Exclusive	UR_Sigma Exclusive	0.51	1.27	0.46	0.75	0.22
UR_Sigma Exclusive	Overlap	0.80	0.51	1.50	0.44	2.21
Gs_all Exclusive	Overlap	0.94	0.95	1.22	1.97	3.10
Overlap	Exclusives	0.65	1.91	4.97	2.43	8.90

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Sigma Exclusive	Gs_all	0.01	-0.12	0.03	-0.36	6.62
Gs_all Exclusive	UR_Sigma	0.01	8.24	2.39	3.71	4.75
UR_Sigma Exclusive	Gs_all Exclusive	0.01	0.19	-0.04	-0.06	5.47
Gs_all Exclusive	UR_Sigma Exclusive	0.01	0.47	-0.11	-0.33	-0.34
UR_Sigma Exclusive	Overlap	0.00	-0.12	1.28	-0.16	0.58
Gs_all Exclusive	Overlap	0.06	101.47	64.47	236.21	147.58
Overlap	Exclusives	0.04	4.79	20.83	8.33	26.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UR_Sigma Exclusive	117	116	VNN 1.00
Gs_all Exclusive	199	176	RTELI;HLA class I;SnoU13;LOC146513; PIGU;ANRIL;TERC; MYNN;LINC00917;SCL22A3;POUF5F1B;7-Mar;LINC00673;CDKN2B-AS1;SAT2B-AS1;LINC00603;COLCA1;SNHG15;HLA class II;METRLN;ZMIZ1-AS1;LINC00675;c11orf53
Overlap	4	4