Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UR_Gene_Embed Exclusive	Gs_all	1.07e-03	3.57e-04	5.44e-49	2.44e-28
Gs_all Exclusive	UR_Gene_Embed	1.65e-08	1.83e-03	5.48e-39	1.97e-39
UR_Gene_Embed Exclusive	Gs_all Exclusive	1.17e-02	1.70e-03	3.12e-42	9.54e-24
Gs_all Exclusive	UR_Gene_Embed Exclusive	3.73e-05	1.18e-02	2.12e-33	2.08e-33
UR_Gene_Embed Exclusive	Overlap	5.62e-05	2.41e-02	1.11e-13	8.19e-10
Gs_all Exclusive	Overlap	4.92e-08	4.02e-06	1.49e-09	6.31e-09
Overlap	Exclusives	1.34e-11	1.66e-11	9.75e-57	3.26e-54



Evaluating how well UR_Gene_Embed genes are linked to Gs_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Gene_Embed Exclusive	Gs_all	0.77	4.60	6.21	4.80	13.78
Gs_all Exclusive	UR_Gene_Embed	0.80	-0.51	3.99	3.46	12.72
UR_Gene_Embed Exclusive	Gs_all Exclusive	0.76	4.08	5.80	4.39	13.57
Gs_all Exclusive	UR_Gene_Embed Exclusive	0.79	-0.96	3.17	3.46	12.69
UR_Gene_Embed Exclusive	Overlap	0.96	2.55	2.94	3.25	5.60
Gs_all Exclusive	Overlap	0.96	2.34	3.86	3.13	6.29
Overlap	Exclusives	0.77	3.70	8.73	4.66	17.48

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Gene_Embed Exclusive	Gs_all	0.05	1.82	13.27	11.26	32.15
Gs_all Exclusive	UR_Gene_Embed	0.08	1.25	20.53	11.97	100.17
UR_Gene_Embed Exclusive	Gs_all Exclusive	0.04	1.85	13.20	10.49	29.31
Gs_all Exclusive	UR_Gene_Embed Exclusive	0.04	-1.94	8.41	6.27	32.75
UR_Gene_Embed Exclusive	Overlap	0.01	-0.74	5.44	9.44	11.11
Gs_all Exclusive	Overlap	0.19	5.33	122.85	102.34	24.09
Overlap	Exclusives	0.08	4.53	32.57	19.54	62.33

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UR_Gene_Embed Exclusive	161	160	SOS 2
Gs_all Exclusive	190	167	c11orf53;RTELI; MYNN;ZMIZ1-AS1;SAT2B-AS1;CDKN2B-AS1;LINC00603;ANRIL; PIGU;SnoU13;LINC00675;7-Mar;METRLN;HLA class II;LINC00673;LINC00917;TERC;LOC146513;SCL22A3;COLCA1;SNHG15;HLA class I;POUF5F1B
Overlap	13	13