Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
UR_Cauchy Exclusive	Gs_all	1.62e-06	3.27e-07	2.91e-35	3.11e-29
Gs_all Exclusive	UR_Cauchy	2.32e-04	2.35e-02	1.63e-13	6.10e-15
UR_Cauchy Exclusive	Gs_all Exclusive	5.08e-06	5.83e-07	1.59e-31	1.00e-24
Gs_all Exclusive	UR_Cauchy Exclusive	9.31e-03	1.74e-02	1.88e-11	5.19e-13
UR_Cauchy Exclusive	Overlap	1.20e-03	8.30e-03	2.61e-06	7.90e-07
Gs_all Exclusive	Overlap	1.05e-06	2.44e-05	2.77e-07	3.59e-07
Overlap	Exclusives	6.20e-08	1.03e-08	5.10e-45	9.18e-35



Evaluating how well UR_Cauchy genes are linked to Gs_all genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Cauchy Exclusive	Gs_all	0.76	3.43	5.58	4.50	12.70
Gs_all Exclusive	UR_Cauchy	0.69	2.05	3.56	4.75	7.70
UR_Cauchy Exclusive	Gs_all Exclusive	0.76	3.69	5.55	4.01	11.21
Gs_all Exclusive	UR_Cauchy Exclusive	0.68	1.78	2.87	3.71	6.67
UR_Cauchy Exclusive	Overlap	0.90	1.71	2.07	2.02	4.71
Gs_all Exclusive	Overlap	0.88	1.59	1.77	1.74	3.99
Overlap	Exclusives	0.73	4.02	9.19	4.11	14.74

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
UR_Cauchy Exclusive	Gs_all	0.06	4.99	16.49	18.18	64.07
Gs_all Exclusive	UR_Cauchy	0.06	3.72	23.76	20.02	70.65
UR_Cauchy Exclusive	Gs_all Exclusive	0.04	4.12	15.74	12.94	43.86
Gs_all Exclusive	UR_Cauchy Exclusive	0.03	-0.64	6.64	7.58	17.36
UR_Cauchy Exclusive	Overlap	0.11	2.85	73.51	77.07	146.96
Gs_all Exclusive	Overlap	0.23	6.09	187.71	113.74	770.34
Overlap	Exclusives	0.06	5.91	29.69	14.93	48.68

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
UR_Cauchy Exclusive	150	148	VNN 1.00;SOS 2
Gs_all Exclusive	193	170	 MYNN;LINC00675;SCL22A3;LOC146513;ZMIZ1-AS1;RTELI;LINC00917;CDKN2B-AS1;c11orf53;ANRIL;METRLN;POUF5F1B;SnoU13; PIGU;COLCA1;SAT2B-AS1;HLA class I;LINC00603;LINC00673;HLA class II;TERC;7-Mar;SNHG15
Overlap	10	10