Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
jorge_run_3_5_64 Exclusive	ad_gs_25	2.71e-01	7.76e-01	5.83e-01	3.21e-01
ad_gs_25 Exclusive	jorge_run_3_5_64	9.55e-01	8.65e-02	3.36e-02	2.21e-02
jorge_run_3_5_64 Exclusive	ad_gs_25 Exclusive	5.03e-01	8.27e-01	9.07e-01	4.89e-01
ad_gs_25 Exclusive	jorge_run_3_5_64 Exclusive	8.96e-01	1.24e-01	3.82e-02	2.70e-02
jorge_run_3_5_64 Exclusive	Overlap	3.42e-01	1.50e-01	4.32e-01	3.04e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.53e-03	5.61e-04	2.08e-13	2.10e-04



Evaluating how well jorge_run_3_5_64 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_3_5_64 Exclusive	ad_gs_25	0.60	0.47	-0.35	-0.13	1.72
ad_gs_25 Exclusive	jorge_run_3_5_64	0.58	1.24	2.38	1.45	2.16
jorge_run_3_5_64 Exclusive	ad_gs_25 Exclusive	0.58	0.16	-0.45	-0.32	1.15
ad_gs_25 Exclusive	jorge_run_3_5_64 Exclusive	0.56	0.62	1.58	1.16	1.88
jorge_run_3_5_64 Exclusive	Overlap	0.75	0.77	0.41	0.50	1.27
ad_gs_25 Exclusive	Overlap	1.00	2.83	2.22	3.06	2.84
Overlap	Exclusives	0.64	4.53	4.13	2.55	4.47

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_3_5_64 Exclusive	ad_gs_25	0.00	0.28	-0.37	-0.16	0.34
ad_gs_25 Exclusive	jorge_run_3_5_64	0.01	2.39	4.31	2.69	3.09
jorge_run_3_5_64 Exclusive	ad_gs_25 Exclusive	0.00	-0.07	-0.66	-0.42	0.05
ad_gs_25 Exclusive	jorge_run_3_5_64 Exclusive	0.00	-0.44	0.37	-0.26	0.35
jorge_run_3_5_64 Exclusive	Overlap	0.00	0.15	0.19	-0.08	0.02
ad_gs_25 Exclusive	Overlap	0.03	71.22	55.52	116.26	93.95
Overlap	Exclusives	0.03	47.36	41.86	17.21	41.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
jorge_run_3_5_64 Exclusive	61	61	
ad_gs_25 Exclusive	22	22	
Overlap	3	3