Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
jorge_run_3_4_74 Exclusive	ad_gs_25	2.71e-01	9.66e-01	8.64e-01	2.67e-01
ad_gs_25 Exclusive	jorge_run_3_4_74	8.18e-01	4.90e-02	1.49e-02	1.24e-02
jorge_run_3_4_74 Exclusive	ad_gs_25 Exclusive	5.58e-01	9.74e-01	9.85e-01	3.33e-01
ad_gs_25 Exclusive	jorge_run_3_4_74 Exclusive	8.98e-01	5.24e-02	3.34e-02	3.62e-02
jorge_run_3_4_74 Exclusive	Overlap	3.82e-01	6.58e-01	5.48e-01	2.82e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	4.02e-03	1.08e-03	7.02e-13	4.06e-04



Evaluating how well jorge_run_3_4_74 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_3_4_74 Exclusive	ad_gs_25	0.62	0.76	-0.06	0.03	2.00
ad_gs_25 Exclusive	jorge_run_3_4_74	0.57	1.63	2.37	1.62	2.39
jorge_run_3_4_74 Exclusive	ad_gs_25 Exclusive	0.60	0.50	-0.29	-0.25	1.58
ad_gs_25 Exclusive	jorge_run_3_4_74 Exclusive	0.55	0.83	2.04	0.84	1.63
jorge_run_3_4_74 Exclusive	Overlap	0.76	1.03	0.31	0.65	1.62
ad_gs_25 Exclusive	Overlap	1.00	2.45	1.95	2.61	3.16
Overlap	Exclusives	0.63	4.10	4.78	2.23	4.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_3_4_74 Exclusive	ad_gs_25	0.00	0.49	-0.37	-0.28	0.48
ad_gs_25 Exclusive	jorge_run_3_4_74	0.01	3.27	4.26	2.65	3.33
jorge_run_3_4_74 Exclusive	ad_gs_25 Exclusive	0.00	0.15	-0.53	-0.39	-0.01
ad_gs_25 Exclusive	jorge_run_3_4_74 Exclusive	0.00	-0.30	1.15	-0.19	0.53
jorge_run_3_4_74 Exclusive	Overlap	0.00	0.01	-0.19	-0.03	0.38
ad_gs_25 Exclusive	Overlap	0.03	101.31	54.13	107.38	88.08
Overlap	Exclusives	0.03	41.07	42.00	22.67	16.40

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
jorge_run_3_4_74 Exclusive	71	71	
ad_gs_25 Exclusive	22	22	
Overlap	3	3