Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
jorge_run_2_9_145 Exclusive	ad_gs_25	3.52e-03	3.39e-02	6.08e-03	8.92e-05
ad_gs_25 Exclusive	jorge_run_2_9_145	9.23e-01	5.16e-02	2.24e-03	2.34e-03
jorge_run_2_9_145 Exclusive	ad_gs_25 Exclusive	3.63e-03	3.20e-02	5.03e-03	4.76e-04
ad_gs_25 Exclusive	jorge_run_2_9_145 Exclusive	8.33e-01	4.77e-02	1.13e-02	6.29e-03
jorge_run_2_9_145 Exclusive	Overlap	2.75e-01	6.76e-01	1.86e-01	6.42e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.62e-02	8.30e-03	1.05e-16	1.78e-03



Evaluating how well jorge_run_2_9_145 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_9_145 Exclusive	ad_gs_25	0.76	2.73	3.10	1.89	4.32
ad_gs_25 Exclusive	jorge_run_2_9_145	0.57	1.34	2.31	1.52	3.03
jorge_run_2_9_145 Exclusive	ad_gs_25 Exclusive	0.74	2.61	2.91	1.92	4.01
ad_gs_25 Exclusive	jorge_run_2_9_145 Exclusive	0.56	1.16	2.14	1.13	2.51
jorge_run_2_9_145 Exclusive	Overlap	0.87	2.02	1.37	1.50	2.12
ad_gs_25 Exclusive	Overlap	1.00	2.79	2.45	3.24	3.47
Overlap	Exclusives	0.59	3.04	3.25	1.77	4.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_9_145 Exclusive	ad_gs_25	0.00	3.48	2.40	0.94	4.81
ad_gs_25 Exclusive	jorge_run_2_9_145	0.01	2.31	4.93	3.27	2.59
jorge_run_2_9_145 Exclusive	ad_gs_25 Exclusive	0.00	2.46	1.55	2.35	1.02
ad_gs_25 Exclusive	jorge_run_2_9_145 Exclusive	0.01	0.44	3.07	1.08	2.78
jorge_run_2_9_145 Exclusive	Overlap	0.00	1.11	0.86	1.52	1.35
ad_gs_25 Exclusive	Overlap	0.03	51.03	65.70	166.86	127.59
Overlap	Exclusives	0.03	27.45	27.51	18.93	20.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
jorge_run_2_9_145 Exclusive	142	142	
ad_gs_25 Exclusive	22	22	
Overlap	3	3