Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
jorge_run_2_7_192 Exclusive	ad_gs_25	1.05e-02	7.91e-03	1.83e-03	3.63e-05
ad_gs_25 Exclusive	jorge_run_2_7_192	5.71e-01	3.01e-02	4.93e-04	4.13e-04
jorge_run_2_7_192 Exclusive	ad_gs_25 Exclusive	5.52e-03	1.74e-02	1.78e-03	1.07e-04
ad_gs_25 Exclusive	jorge_run_2_7_192 Exclusive	5.39e-01	6.19e-02	1.96e-03	6.93e-04
jorge_run_2_7_192 Exclusive	Overlap	4.58e-01	6.40e-01	2.16e-01	3.72e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	1.09e-01	5.52e-02	3.29e-19	1.29e-03



Evaluating how well jorge_run_2_7_192 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_7_192 Exclusive	ad_gs_25	0.78	2.08	3.57	2.35	4.97
ad_gs_25 Exclusive	jorge_run_2_7_192	0.56	1.31	2.35	1.54	3.10
jorge_run_2_7_192 Exclusive	ad_gs_25 Exclusive	0.76	2.93	3.23	2.07	4.48
ad_gs_25 Exclusive	jorge_run_2_7_192 Exclusive	0.56	1.30	1.96	1.29	2.83
jorge_run_2_7_192 Exclusive	Overlap	0.88	2.01	1.17	2.02	2.21
ad_gs_25 Exclusive	Overlap	1.00	3.23	1.93	2.95	3.35
Overlap	Exclusives	0.59	2.91	3.15	1.67	4.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_7_192 Exclusive	ad_gs_25	0.00	2.78	1.83	2.52	2.30
ad_gs_25 Exclusive	jorge_run_2_7_192	0.01	2.43	4.09	3.91	5.51
jorge_run_2_7_192 Exclusive	ad_gs_25 Exclusive	0.00	3.96	2.55	3.10	5.97
ad_gs_25 Exclusive	jorge_run_2_7_192 Exclusive	0.01	1.13	2.36	1.41	1.93
jorge_run_2_7_192 Exclusive	Overlap	0.00	-0.00	-3.50	0.31	1.05
ad_gs_25 Exclusive	Overlap	0.03	84.79	56.21	143.81	3.74
Overlap	Exclusives	0.03	17.72	21.18	14.29	17.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
jorge_run_2_7_192 Exclusive	189	189	
ad_gs_25 Exclusive	22	22	
Overlap	3	3