Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
jorge_run_2_6_248 Exclusive	ad_gs_25	4.07e-03	1.18e-03	6.30e-04	1.93e-05
ad_gs_25 Exclusive	jorge_run_2_6_248	2.27e-01	1.50e-01	3.91e-03	2.05e-03
jorge_run_2_6_248 Exclusive	ad_gs_25 Exclusive	5.86e-03	2.17e-03	4.76e-04	5.19e-05
ad_gs_25 Exclusive	jorge_run_2_6_248 Exclusive	2.67e-01	1.28e-01	6.09e-03	3.76e-03
jorge_run_2_6_248 Exclusive	Overlap	5.66e-01	7.89e-01	5.75e-01	7.48e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.14e-01	6.07e-02	2.37e-24	1.78e-04



Evaluating how well jorge_run_2_6_248 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_6_248 Exclusive	ad_gs_25	0.78	2.33	3.53	2.40	4.93
ad_gs_25 Exclusive	jorge_run_2_6_248	0.56	1.13	2.02	1.21	2.87
jorge_run_2_6_248 Exclusive	ad_gs_25 Exclusive	0.77	2.45	3.83	2.26	4.04
ad_gs_25 Exclusive	jorge_run_2_6_248 Exclusive	0.55	0.94	1.77	1.24	3.14
jorge_run_2_6_248 Exclusive	Overlap	0.86	1.87	0.92	1.56	2.04
ad_gs_25 Exclusive	Overlap	1.00	2.84	2.11	2.86	2.90
Overlap	Exclusives	0.58	3.32	3.07	2.23	4.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_6_248 Exclusive	ad_gs_25	0.00	3.16	3.03	3.54	6.36
ad_gs_25 Exclusive	jorge_run_2_6_248	0.02	2.28	3.78	2.26	4.24
jorge_run_2_6_248 Exclusive	ad_gs_25 Exclusive	0.00	3.96	4.02	2.93	2.32
ad_gs_25 Exclusive	jorge_run_2_6_248 Exclusive	0.02	1.17	2.19	1.43	2.71
jorge_run_2_6_248 Exclusive	Overlap	0.00	1.12	1.81	4.07	6.09
ad_gs_25 Exclusive	Overlap	0.03	110.44	52.74	101.67	48.12
Overlap	Exclusives	0.03	20.08	19.00	11.96	18.71

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
jorge_run_2_6_248 Exclusive	245	245	
ad_gs_25 Exclusive	22	22	
Overlap	3	3