Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
jorge_run_2_2_554 Exclusive	ad_gs_25	1.72e-03	3.03e-03	5.51e-05	7.84e-08
ad_gs_25 Exclusive	jorge_run_2_2_554	1.10e-01	3.29e-02	4.41e-07	6.18e-07
jorge_run_2_2_554 Exclusive	ad_gs_25 Exclusive	4.81e-03	1.63e-03	3.69e-05	1.97e-06
ad_gs_25 Exclusive	jorge_run_2_2_554 Exclusive	1.60e-01	3.90e-02	2.57e-07	6.17e-07
jorge_run_2_2_554 Exclusive	Overlap	4.32e-01	6.58e-01	2.68e-01	1.34e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	4.73e-01	4.60e-02	3.69e-53	1.51e-08



Evaluating how well jorge_run_2_2_554 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_2_554 Exclusive	ad_gs_25	0.82	4.14	4.43	3.00	6.21
ad_gs_25 Exclusive	jorge_run_2_2_554	0.56	2.03	2.60	2.41	5.27
jorge_run_2_2_554 Exclusive	ad_gs_25 Exclusive	0.81	3.79	5.06	3.29	4.73
ad_gs_25 Exclusive	jorge_run_2_2_554 Exclusive	0.56	2.09	2.67	1.87	4.87
jorge_run_2_2_554 Exclusive	Overlap	0.87	2.13	1.03	1.53	2.58
ad_gs_25 Exclusive	Overlap	1.00	3.13	2.23	2.81	3.02
Overlap	Exclusives	0.57	2.15	3.05	1.75	5.93

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_2_554 Exclusive	ad_gs_25	0.01	6.48	7.58	4.11	1.00
ad_gs_25 Exclusive	jorge_run_2_2_554	0.04	3.19	4.94	4.38	6.50
jorge_run_2_2_554 Exclusive	ad_gs_25 Exclusive	0.00	7.15	10.25	6.66	8.81
ad_gs_25 Exclusive	jorge_run_2_2_554 Exclusive	0.04	2.90	3.92	3.02	5.54
jorge_run_2_2_554 Exclusive	Overlap	0.00	1.00	5.39	1.39	3.15
ad_gs_25 Exclusive	Overlap	0.03	64.96	49.87	95.73	195.21
Overlap	Exclusives	0.04	11.05	11.06	6.66	12.22

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
jorge_run_2_2_554 Exclusive	551	550	PTGES3L-AARSD1
ad_gs_25 Exclusive	22	22	
Overlap	3	3