Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
jorge_run_2_1_692 Exclusive	ad_gs_25	9.82e-03	5.35e-03	5.32e-04	5.86e-06
ad_gs_25 Exclusive	jorge_run_2_1_692	1.19e-01	2.52e-02	2.93e-08	1.98e-07
jorge_run_2_1_692 Exclusive	ad_gs_25 Exclusive	3.52e-03	1.69e-03	1.16e-04	4.47e-05
ad_gs_25 Exclusive	jorge_run_2_1_692 Exclusive	1.30e-01	1.81e-02	8.05e-11	1.69e-07
jorge_run_2_1_692 Exclusive	Overlap	8.25e-01	7.89e-01	5.48e-01	3.86e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.52e-01	9.58e-02	7.39e-59	1.40e-07



Evaluating how well jorge_run_2_1_692 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_1_692 Exclusive	ad_gs_25	0.82	3.83	4.31	3.05	5.46
ad_gs_25 Exclusive	jorge_run_2_1_692	0.56	2.59	3.10	2.05	6.26
jorge_run_2_1_692 Exclusive	ad_gs_25 Exclusive	0.81	3.72	4.86	3.29	4.90
ad_gs_25 Exclusive	jorge_run_2_1_692 Exclusive	0.56	2.27	2.77	2.39	5.29
jorge_run_2_1_692 Exclusive	Overlap	0.85	1.32	0.60	1.48	2.51
ad_gs_25 Exclusive	Overlap	1.00	2.86	2.36	2.68	2.85
Overlap	Exclusives	0.57	2.68	3.27	1.77	6.39

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_1_692 Exclusive	ad_gs_25	0.01	6.71	8.24	4.84	14.21
ad_gs_25 Exclusive	jorge_run_2_1_692	0.04	3.64	4.75	3.50	7.55
jorge_run_2_1_692 Exclusive	ad_gs_25 Exclusive	0.00	6.49	9.31	6.13	5.22
ad_gs_25 Exclusive	jorge_run_2_1_692 Exclusive	0.04	2.66	3.50	3.37	5.31
jorge_run_2_1_692 Exclusive	Overlap	0.00	2.33	9.43	3.19	1.17
ad_gs_25 Exclusive	Overlap	0.03	129.69	65.74	70.40	29.83
Overlap	Exclusives	0.05	8.69	8.60	5.76	11.30

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
jorge_run_2_1_692 Exclusive	689	687	STON1-GTF2A1L;PTGES3L-AARSD1
ad_gs_25 Exclusive	22	22	
Overlap	3	3