Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
jorge_run_2_1_845 Exclusive	ad_gs_25	6.96e-02	5.62e-02	2.46e-03	4.10e-05
ad_gs_25 Exclusive	jorge_run_2_1_845	3.75e-03	9.08e-02	3.09e-08	7.19e-07
jorge_run_2_1_845 Exclusive	ad_gs_25 Exclusive	9.51e-02	5.97e-02	3.41e-03	1.95e-04
ad_gs_25 Exclusive	jorge_run_2_1_845 Exclusive	2.61e-03	7.86e-02	6.06e-09	2.60e-06
jorge_run_2_1_845 Exclusive	Overlap	8.75e-01	7.89e-01	8.13e-01	1.41e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	5.17e-02	1.67e-01	1.53e-81	3.17e-07



Evaluating how well jorge_run_2_1_845 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_1_845 Exclusive	ad_gs_25	0.77	2.06	3.11	2.42	4.32
ad_gs_25 Exclusive	jorge_run_2_1_845	0.55	0.99	1.61	1.41	5.16
jorge_run_2_1_845 Exclusive	ad_gs_25 Exclusive	0.77	2.35	2.99	2.51	4.32
ad_gs_25 Exclusive	jorge_run_2_1_845 Exclusive	0.54	1.02	1.72	1.21	4.60
jorge_run_2_1_845 Exclusive	Overlap	0.83	1.12	0.39	1.12	2.11
ad_gs_25 Exclusive	Overlap	1.00	3.06	2.24	3.02	2.94
Overlap	Exclusives	0.56	1.65	2.74	1.50	6.40

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_2_1_845 Exclusive	ad_gs_25	0.00	2.03	5.06	3.07	8.42
ad_gs_25 Exclusive	jorge_run_2_1_845	0.05	1.59	2.80	2.38	5.33
jorge_run_2_1_845 Exclusive	ad_gs_25 Exclusive	0.00	2.50	4.63	2.77	5.45
ad_gs_25 Exclusive	jorge_run_2_1_845 Exclusive	0.05	1.09	1.70	1.74	3.64
jorge_run_2_1_845 Exclusive	Overlap	0.00	1.64	6.46	3.01	15.21
ad_gs_25 Exclusive	Overlap	0.03	81.90	60.20	125.50	82.12
Overlap	Exclusives	0.06	7.13	7.09	4.66	10.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
jorge_run_2_1_845 Exclusive	842	839	PTGES3L-AARSD1;UGT2A1;STON1-GTF2A1L
ad_gs_25 Exclusive	22	22	
Overlap	3	3