Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
jorge_run_1_5_2094 Exclusive	ad_gs_25	4.49e-01	4.58e-01	4.87e-02	3.39e-04
ad_gs_25 Exclusive	jorge_run_1_5_2094	1.43e-03	5.60e-02	9.44e-20	8.78e-12
jorge_run_1_5_2094 Exclusive	ad_gs_25 Exclusive	4.31e-01	3.98e-01	5.12e-02	2.81e-03
ad_gs_25 Exclusive	jorge_run_1_5_2094 Exclusive	2.33e-04	6.10e-02	1.14e-15	2.25e-11
jorge_run_1_5_2094 Exclusive	Overlap	8.62e-01	5.71e-01	3.37e-01	3.22e-02
ad_gs_25 Exclusive	Overlap	2.09e-13	2.98e-14	2.09e-13	8.35e-13
Overlap	Exclusives	2.54e-07	8.48e-03	1.61e-136	2.15e-13



Evaluating how well jorge_run_1_5_2094 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_1_5_2094 Exclusive	ad_gs_25	0.73	1.32	1.60	1.30	4.34
ad_gs_25 Exclusive	jorge_run_1_5_2094	0.55	1.19	2.64	1.50	8.42
jorge_run_1_5_2094 Exclusive	ad_gs_25 Exclusive	0.72	1.97	2.06	1.82	3.54
ad_gs_25 Exclusive	jorge_run_1_5_2094 Exclusive	0.55	0.97	2.68	1.37	7.19
jorge_run_1_5_2094 Exclusive	Overlap	0.78	-0.75	-0.70	-0.25	2.66
ad_gs_25 Exclusive	Overlap	1.00	3.54	4.62	3.37	4.07
Overlap	Exclusives	0.55	2.12	2.76	1.02	9.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
jorge_run_1_5_2094 Exclusive	ad_gs_25	0.00	1.16	2.36	1.76	5.47
ad_gs_25 Exclusive	jorge_run_1_5_2094	0.12	1.67	2.90	2.28	6.79
jorge_run_1_5_2094 Exclusive	ad_gs_25 Exclusive	0.00	2.14	2.62	2.00	1.64
ad_gs_25 Exclusive	jorge_run_1_5_2094 Exclusive	0.12	0.91	2.25	1.54	5.16
jorge_run_1_5_2094 Exclusive	Overlap	0.00	0.46	0.90	1.66	0.67
ad_gs_25 Exclusive	Overlap	0.08	143.11	189.31	225.54	338.01
Overlap	Exclusives	0.12	3.61	3.24	1.82	7.55

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
jorge_run_1_5_2094 Exclusive	2086	2077	PRAMEF11;PTGES3L-AARSD1;STON1-GTF2A1L;MFRP;C19orf84;UGT2A1;RPL17-C18orf32;CROCC2;FAM47E-STBD1
ad_gs_25 Exclusive	19	19	
Overlap	6	6