Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_3_5_62 Exclusive	ad_gs_25	9.00e-02	3.19e-01	2.54e-01	1.29e-01
ad_gs_25 Exclusive	10000run_3_5_62	7.35e-01	9.03e-02	3.43e-02	2.49e-02
10000run_3_5_62 Exclusive	ad_gs_25 Exclusive	2.90e-01	3.89e-01	5.76e-01	3.25e-01
ad_gs_25 Exclusive	10000run_3_5_62 Exclusive	9.36e-01	9.34e-02	2.38e-02	9.66e-02
10000run_3_5_62 Exclusive	Overlap	2.68e-01	8.57e-01	4.94e-01	2.10e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.68e-03	4.09e-04	1.64e-13	3.94e-05



Evaluating how well 10000run_3_5_62 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_3_5_62 Exclusive	ad_gs_25	0.61	0.61	0.04	0.03	1.69
ad_gs_25 Exclusive	10000run_3_5_62	0.58	1.77	2.37	1.75	2.23
10000run_3_5_62 Exclusive	ad_gs_25 Exclusive	0.59	0.21	0.03	-0.25	1.54
ad_gs_25 Exclusive	10000run_3_5_62 Exclusive	0.56	1.16	2.03	1.43	1.42
10000run_3_5_62 Exclusive	Overlap	0.75	0.87	0.16	0.55	1.60
ad_gs_25 Exclusive	Overlap	1.00	3.03	2.03	2.65	2.87
Overlap	Exclusives	0.65	3.95	4.35	2.52	4.88

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_3_5_62 Exclusive	ad_gs_25	0.00	0.42	0.35	0.20	0.27
ad_gs_25 Exclusive	10000run_3_5_62	0.01	1.02	5.16	2.67	2.66
10000run_3_5_62 Exclusive	ad_gs_25 Exclusive	0.00	0.18	0.45	-0.14	0.32
ad_gs_25 Exclusive	10000run_3_5_62 Exclusive	0.00	-0.09	0.61	-0.13	0.44
10000run_3_5_62 Exclusive	Overlap	0.00	0.41	0.03	0.10	1.13
ad_gs_25 Exclusive	Overlap	0.03	130.94	47.51	94.70	50.30
Overlap	Exclusives	0.03	33.92	35.77	15.10	18.72

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_3_5_62 Exclusive	59	59	
ad_gs_25 Exclusive	22	22	
Overlap	3	3