Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_3_3_78 Exclusive	ad_gs_25	1.50e-01	4.61e-01	4.52e-01	1.19e-01
ad_gs_25 Exclusive	10000run_3_3_78	5.17e-01	2.45e-02	2.48e-03	4.71e-03
10000run_3_3_78 Exclusive	ad_gs_25 Exclusive	2.34e-01	3.71e-01	5.06e-01	1.63e-01
ad_gs_25 Exclusive	10000run_3_3_78 Exclusive	6.23e-01	2.74e-02	2.89e-03	3.54e-02
10000run_3_3_78 Exclusive	Overlap	2.54e-01	8.57e-01	6.12e-01	2.10e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	8.71e-06
Overlap	Exclusives	3.86e-03	4.59e-04	5.26e-15	1.46e-04



Evaluating how well 10000run_3_3_78 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_3_3_78 Exclusive	ad_gs_25	0.64	1.10	0.61	0.54	2.39
ad_gs_25 Exclusive	10000run_3_3_78	0.57	1.86	2.30	2.28	2.45
10000run_3_3_78 Exclusive	ad_gs_25 Exclusive	0.62	0.81	0.83	0.30	1.73
ad_gs_25 Exclusive	10000run_3_3_78 Exclusive	0.56	1.51	2.22	1.74	1.76
10000run_3_3_78 Exclusive	Overlap	0.78	1.06	0.76	0.77	1.43
ad_gs_25 Exclusive	Overlap	1.00	2.88	2.23	3.24	2.89
Overlap	Exclusives	0.63	4.01	5.15	2.09	4.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_3_3_78 Exclusive	ad_gs_25	0.00	0.50	0.41	0.11	0.70
ad_gs_25 Exclusive	10000run_3_3_78	0.01	1.15	3.69	1.30	3.66
10000run_3_3_78 Exclusive	ad_gs_25 Exclusive	0.00	0.31	0.30	0.01	0.18
ad_gs_25 Exclusive	10000run_3_3_78 Exclusive	0.00	0.08	1.18	0.22	0.42
10000run_3_3_78 Exclusive	Overlap	0.00	0.98	0.43	0.04	1.12
ad_gs_25 Exclusive	Overlap	0.03	102.83	66.14	136.55	46.85
Overlap	Exclusives	0.03	36.22	34.78	9.31	28.52

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_3_3_78 Exclusive	75	75	
ad_gs_25 Exclusive	22	22	
Overlap	3	3