Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 10000run_3_2_88 Exclusive ad_gs_25 1.87e-01 6.84e-01 5.63e-01 1.09e-01 ad_gs_25 Exclusive 10000run_3_2_88 6.80e-01 3.06e-02 4.32e-03 2.35e-02 10000run_3_2_88 Exclusive ad_gs_25 Exclusive 3.35e-01 6.51e-01 8.74e-01 2.57e-01 ad_gs_25 Exclusive 10000run_3_2_88 Exclusive 7.11e-01 3.88e-02 1.28e-02 5.54e-02 10000run_3_2_88 Exclusive Overlap 2.68e-01 7.31e-01 6.76e-01 2.75e-01 ad_gs_25 Exclusive Overlap 4.36e-07 4.36e-07 4.36e-07 4.36e-07 Overlap Exclusives 8.42e-03 1.22e-03 1.27e-14 3.20e-04 Evaluating how well 10000run_3_2_88 genes are linked to ad_gs_25 genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 10000run_3_2_88 Exclusive ad_gs_25 0.62 0.60 0.28 0.21 2.28 ad_gs_25 Exclusive 10000run_3_2_88 0.56 1.34 2.51 1.57 1.59 10000run_3_2_88 Exclusive ad_gs_25 Exclusive 0.60 0.39 0.24 -0.13 1.46 ad_gs_25 Exclusive 10000run_3_2_88 Exclusive 0.54 1.30 1.59 0.96 1.28 10000run_3_2_88 Exclusive Overlap 0.77 1.43 0.53 0.71 1.46 ad_gs_25 Exclusive Overlap 1.00 2.77 2.17 3.10 2.87 Overlap Exclusives 0.61 3.84 4.65 2.12 4.16 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 10000run_3_2_88 Exclusive ad_gs_25 0.00 0.38 -0.15 -0.06 -0.03 ad_gs_25 Exclusive 10000run_3_2_88 0.01 2.07 4.43 2.68 2.74 10000run_3_2_88 Exclusive ad_gs_25 Exclusive 0.00 0.10 -0.20 -0.32 0.25 ad_gs_25 Exclusive 10000run_3_2_88 Exclusive 0.00 0.01 1.14 -0.19 -0.02 10000run_3_2_88 Exclusive Overlap 0.00 1.45 -0.13 0.14 0.16 ad_gs_25 Exclusive Overlap 0.03 72.99 62.63 225.53 161.97 Overlap Exclusives 0.03 30.15 36.70 17.89 32.88 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 10000run_3_2_88 Exclusive 85 85 ad_gs_25 Exclusive 22 22 Overlap 3 3