Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_3_1_102 Exclusive	ad_gs_25	3.70e-01	8.67e-01	8.28e-01	8.38e-02
ad_gs_25 Exclusive	10000run_3_1_102	5.88e-01	4.66e-02	9.08e-03	7.16e-03
10000run_3_1_102 Exclusive	ad_gs_25 Exclusive	7.51e-01	9.92e-01	9.85e-01	1.84e-01
ad_gs_25 Exclusive	10000run_3_1_102 Exclusive	5.94e-01	4.48e-02	8.15e-03	2.11e-02
10000run_3_1_102 Exclusive	Overlap	1.92e-01	7.49e-01	4.32e-01	1.98e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	1.34e-02	1.18e-03	5.60e-17	1.21e-03



Evaluating how well 10000run_3_1_102 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_3_1_102 Exclusive	ad_gs_25	0.62	0.74	0.34	0.16	1.96
ad_gs_25 Exclusive	10000run_3_1_102	0.55	1.54	2.05	1.14	2.07
10000run_3_1_102 Exclusive	ad_gs_25 Exclusive	0.60	0.34	0.08	-0.12	1.67
ad_gs_25 Exclusive	10000run_3_1_102 Exclusive	0.54	1.05	1.83	1.01	1.50
10000run_3_1_102 Exclusive	Overlap	0.78	1.33	0.62	0.72	1.66
ad_gs_25 Exclusive	Overlap	1.00	3.19	2.05	2.88	2.64
Overlap	Exclusives	0.61	2.91	4.32	2.34	4.10

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_3_1_102 Exclusive	ad_gs_25	0.00	0.50	-0.27	-0.18	0.56
ad_gs_25 Exclusive	10000run_3_1_102	0.01	1.73	3.55	0.58	2.84
10000run_3_1_102 Exclusive	ad_gs_25 Exclusive	0.00	0.01	-0.58	-0.44	0.05
ad_gs_25 Exclusive	10000run_3_1_102 Exclusive	0.01	-0.13	1.17	-0.12	0.17
10000run_3_1_102 Exclusive	Overlap	0.00	1.41	0.31	0.16	0.59
ad_gs_25 Exclusive	Overlap	0.03	113.96	74.78	120.03	9.48
Overlap	Exclusives	0.02	27.73	37.28	14.07	18.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_3_1_102 Exclusive	99	99	
ad_gs_25 Exclusive	22	22	
Overlap	3	3