Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_3_120 Exclusive	ad_gs_25	3.14e-01	9.29e-01	4.31e-01	4.66e-02
ad_gs_25 Exclusive	10000run_3_120	7.63e-01	9.78e-03	2.78e-03	1.25e-02
10000run_3_120 Exclusive	ad_gs_25 Exclusive	2.48e-01	9.86e-01	5.65e-01	6.04e-02
ad_gs_25 Exclusive	10000run_3_120 Exclusive	7.63e-01	1.09e-02	4.57e-03	2.01e-02
10000run_3_120 Exclusive	Overlap	2.61e-01	8.93e-01	3.11e-01	1.92e-01
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.10e-02	3.14e-03	5.35e-16	1.38e-03



Evaluating how well 10000run_3_120 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_3_120 Exclusive	ad_gs_25	0.64	0.75	0.70	0.34	2.47
ad_gs_25 Exclusive	10000run_3_120	0.56	1.47	2.72	1.76	2.43
10000run_3_120 Exclusive	ad_gs_25 Exclusive	0.62	0.81	0.14	0.06	2.17
ad_gs_25 Exclusive	10000run_3_120 Exclusive	0.55	1.17	1.88	1.32	1.87
10000run_3_120 Exclusive	Overlap	0.76	1.17	0.42	0.72	1.61
ad_gs_25 Exclusive	Overlap	1.00	2.70	2.08	2.70	3.31
Overlap	Exclusives	0.59	3.52	4.08	1.80	4.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_3_120 Exclusive	ad_gs_25	0.00	0.33	-0.25	-0.05	0.23
ad_gs_25 Exclusive	10000run_3_120	0.01	1.41	3.83	1.05	1.53
10000run_3_120 Exclusive	ad_gs_25 Exclusive	0.00	0.25	-0.56	-0.37	0.56
ad_gs_25 Exclusive	10000run_3_120 Exclusive	0.01	-0.07	1.19	0.10	0.61
10000run_3_120 Exclusive	Overlap	0.00	0.80	0.78	0.67	1.09
ad_gs_25 Exclusive	Overlap	0.03	70.42	64.65	115.77	67.84
Overlap	Exclusives	0.02	24.67	26.32	9.08	25.67

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_3_120 Exclusive	117	117	
ad_gs_25 Exclusive	22	22	
Overlap	3	3