Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_2_9_143 Exclusive	ad_gs_25	4.80e-04	1.53e-02	1.89e-03	5.19e-05
ad_gs_25 Exclusive	10000run_2_9_143	9.00e-01	2.68e-02	2.10e-02	1.57e-02
10000run_2_9_143 Exclusive	ad_gs_25 Exclusive	1.72e-03	1.12e-02	1.01e-02	2.41e-04
ad_gs_25 Exclusive	10000run_2_9_143 Exclusive	8.72e-01	5.09e-02	3.16e-02	1.76e-02
10000run_2_9_143 Exclusive	Overlap	1.98e-01	5.66e-01	1.98e-01	3.19e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-06
Overlap	Exclusives	2.31e-02	5.92e-03	3.27e-18	1.92e-04



Evaluating how well 10000run_2_9_143 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_9_143 Exclusive	ad_gs_25	0.77	2.90	3.29	2.21	4.54
ad_gs_25 Exclusive	10000run_2_9_143	0.57	1.87	2.59	1.98	2.53
10000run_2_9_143 Exclusive	ad_gs_25 Exclusive	0.75	2.56	3.42	1.98	4.04
ad_gs_25 Exclusive	10000run_2_9_143 Exclusive	0.56	1.29	2.11	1.21	2.75
10000run_2_9_143 Exclusive	Overlap	0.88	2.22	1.42	1.75	2.33
ad_gs_25 Exclusive	Overlap	1.00	2.69	2.40	2.88	3.11
Overlap	Exclusives	0.59	3.11	3.86	2.09	4.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_9_143 Exclusive	ad_gs_25	0.00	3.00	2.29	1.47	3.58
ad_gs_25 Exclusive	10000run_2_9_143	0.01	4.02	5.63	2.22	5.09
10000run_2_9_143 Exclusive	ad_gs_25 Exclusive	0.00	1.51	2.15	1.23	0.73
ad_gs_25 Exclusive	10000run_2_9_143 Exclusive	0.01	1.07	3.14	1.49	2.33
10000run_2_9_143 Exclusive	Overlap	0.00	1.50	1.20	1.54	2.01
ad_gs_25 Exclusive	Overlap	0.03	68.63	70.35	176.21	45.87
Overlap	Exclusives	0.03	23.46	30.23	11.51	27.47

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_2_9_143 Exclusive	140	140	
ad_gs_25 Exclusive	22	22	
Overlap	3	3