Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_2_8_167 Exclusive	ad_gs_25	4.18e-05	1.14e-04	6.83e-06	1.37e-06
ad_gs_25 Exclusive	10000run_2_8_167	8.21e-01	1.38e-02	6.43e-04	3.71e-04
10000run_2_8_167 Exclusive	ad_gs_25 Exclusive	5.19e-05	9.11e-05	1.95e-05	9.21e-06
ad_gs_25 Exclusive	10000run_2_8_167 Exclusive	8.28e-01	3.35e-02	3.53e-03	7.27e-04
10000run_2_8_167 Exclusive	Overlap	3.42e-01	5.03e-01	1.75e-01	4.00e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	3.95e-02	8.65e-03	6.11e-22	4.95e-04



Evaluating how well 10000run_2_8_167 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_8_167 Exclusive	ad_gs_25	0.80	2.81	4.17	2.96	5.37
ad_gs_25 Exclusive	10000run_2_8_167	0.58	1.68	3.02	2.07	3.49
10000run_2_8_167 Exclusive	ad_gs_25 Exclusive	0.79	2.81	4.26	2.78	4.59
ad_gs_25 Exclusive	10000run_2_8_167 Exclusive	0.57	1.47	2.53	1.50	3.09
10000run_2_8_167 Exclusive	Overlap	0.89	2.06	1.60	1.89	2.30
ad_gs_25 Exclusive	Overlap	1.00	3.17	2.15	2.77	3.36
Overlap	Exclusives	0.60	3.21	3.32	1.98	4.82

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_8_167 Exclusive	ad_gs_25	0.01	4.78	3.29	5.60	6.20
ad_gs_25 Exclusive	10000run_2_8_167	0.01	3.82	5.47	4.57	3.73
10000run_2_8_167 Exclusive	ad_gs_25 Exclusive	0.00	5.64	3.58	3.98	2.98
ad_gs_25 Exclusive	10000run_2_8_167 Exclusive	0.01	1.12	3.30	1.81	1.94
10000run_2_8_167 Exclusive	Overlap	0.00	0.46	1.21	1.77	0.28
ad_gs_25 Exclusive	Overlap	0.03	105.58	57.77	160.47	94.25
Overlap	Exclusives	0.03	28.04	23.81	17.47	18.92

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_2_8_167 Exclusive	164	164	
ad_gs_25 Exclusive	22	22	
Overlap	3	3