Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_2_7_199 Exclusive	ad_gs_25	1.92e-03	1.47e-03	7.45e-04	1.17e-05
ad_gs_25 Exclusive	10000run_2_7_199	7.16e-01	2.29e-02	4.70e-04	5.69e-04
10000run_2_7_199 Exclusive	ad_gs_25 Exclusive	2.77e-03	2.10e-03	7.49e-04	5.89e-05
ad_gs_25 Exclusive	10000run_2_7_199 Exclusive	4.40e-01	4.53e-02	1.11e-03	1.02e-03
10000run_2_7_199 Exclusive	Overlap	3.82e-01	6.76e-01	3.42e-01	3.19e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.42e-01	2.69e-02	2.31e-21	6.87e-04



Evaluating how well 10000run_2_7_199 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_7_199 Exclusive	ad_gs_25	0.79	2.68	4.76	2.46	5.00
ad_gs_25 Exclusive	10000run_2_7_199	0.57	1.34	2.49	1.84	3.11
10000run_2_7_199 Exclusive	ad_gs_25 Exclusive	0.78	2.33	3.74	2.35	4.44
ad_gs_25 Exclusive	10000run_2_7_199 Exclusive	0.56	1.18	2.07	1.88	2.54
10000run_2_7_199 Exclusive	Overlap	0.87	2.14	1.11	1.60	2.52
ad_gs_25 Exclusive	Overlap	1.00	2.79	2.18	2.87	3.03
Overlap	Exclusives	0.59	2.40	3.59	2.09	4.92

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_7_199 Exclusive	ad_gs_25	0.00	3.01	1.59	2.60	5.15
ad_gs_25 Exclusive	10000run_2_7_199	0.01	2.51	4.38	3.91	3.85
10000run_2_7_199 Exclusive	ad_gs_25 Exclusive	0.00	3.14	1.90	2.53	0.33
ad_gs_25 Exclusive	10000run_2_7_199 Exclusive	0.01	0.51	2.04	1.11	2.52
10000run_2_7_199 Exclusive	Overlap	0.00	0.14	-2.50	0.59	3.85
ad_gs_25 Exclusive	Overlap	0.03	81.53	57.21	168.43	71.23
Overlap	Exclusives	0.03	20.86	20.71	14.85	19.63

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_2_7_199 Exclusive	196	196	
ad_gs_25 Exclusive	22	22	
Overlap	3	3