Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_2_6_245 Exclusive	ad_gs_25	6.89e-03	1.83e-03	4.40e-04	1.03e-05
ad_gs_25 Exclusive	10000run_2_6_245	2.90e-01	1.67e-01	6.65e-04	1.35e-03
10000run_2_6_245 Exclusive	ad_gs_25 Exclusive	3.58e-03	2.39e-03	2.15e-04	4.67e-05
ad_gs_25 Exclusive	10000run_2_6_245 Exclusive	2.05e-01	1.49e-01	1.92e-03	2.34e-03
10000run_2_6_245 Exclusive	Overlap	5.75e-01	7.89e-01	4.58e-01	8.78e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.25e-01	1.14e-01	4.16e-25	5.68e-04



Evaluating how well 10000run_2_6_245 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_6_245 Exclusive	ad_gs_25	0.77	2.37	3.54	2.06	4.94
ad_gs_25 Exclusive	10000run_2_6_245	0.56	1.20	1.89	1.21	3.14
10000run_2_6_245 Exclusive	ad_gs_25 Exclusive	0.76	2.29	3.14	2.40	4.80
ad_gs_25 Exclusive	10000run_2_6_245 Exclusive	0.55	0.75	2.01	1.06	3.28
10000run_2_6_245 Exclusive	Overlap	0.86	1.88	0.97	1.35	1.97
ad_gs_25 Exclusive	Overlap	1.00	2.82	2.17	2.77	3.29
Overlap	Exclusives	0.58	2.99	3.39	1.70	5.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_6_245 Exclusive	ad_gs_25	0.00	3.92	3.78	1.97	4.50
ad_gs_25 Exclusive	10000run_2_6_245	0.02	1.85	3.68	2.99	4.43
10000run_2_6_245 Exclusive	ad_gs_25 Exclusive	0.00	3.35	3.52	4.31	6.07
ad_gs_25 Exclusive	10000run_2_6_245 Exclusive	0.02	0.77	2.17	1.81	2.47
10000run_2_6_245 Exclusive	Overlap	0.00	1.48	-0.29	1.39	2.93
ad_gs_25 Exclusive	Overlap	0.03	39.77	62.85	100.63	102.16
Overlap	Exclusives	0.03	19.95	21.15	9.11	18.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_2_6_245 Exclusive	242	242	
ad_gs_25 Exclusive	22	22	
Overlap	3	3