Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_2_5_292 Exclusive	ad_gs_25	1.37e-02	1.12e-02	1.50e-03	1.51e-05
ad_gs_25 Exclusive	10000run_2_5_292	4.15e-01	2.17e-01	3.26e-03	1.24e-03
10000run_2_5_292 Exclusive	ad_gs_25 Exclusive	1.30e-02	6.32e-03	3.36e-03	1.34e-04
ad_gs_25 Exclusive	10000run_2_5_292 Exclusive	2.10e-01	1.91e-01	5.22e-04	2.25e-03
10000run_2_5_292 Exclusive	Overlap	4.76e-01	6.49e-01	3.74e-01	5.12e-02
ad_gs_25 Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.05e-01	6.93e-02	2.04e-22	6.11e-04



Evaluating how well 10000run_2_5_292 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_5_292 Exclusive	ad_gs_25	0.77	2.84	3.65	2.47	4.43
ad_gs_25 Exclusive	10000run_2_5_292	0.56	1.57	1.84	1.50	2.90
10000run_2_5_292 Exclusive	ad_gs_25 Exclusive	0.76	2.69	3.39	1.60	4.56
ad_gs_25 Exclusive	10000run_2_5_292 Exclusive	0.55	0.88	1.71	1.05	3.42
10000run_2_5_292 Exclusive	Overlap	0.87	1.84	1.37	1.68	2.63
ad_gs_25 Exclusive	Overlap	1.00	2.87	2.32	2.95	3.33
Overlap	Exclusives	0.57	2.56	2.48	1.56	4.91

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_2_5_292 Exclusive	ad_gs_25	0.00	3.36	3.47	2.86	3.16
ad_gs_25 Exclusive	10000run_2_5_292	0.02	2.23	3.16	3.38	4.38
10000run_2_5_292 Exclusive	ad_gs_25 Exclusive	0.00	3.43	4.29	1.35	2.47
ad_gs_25 Exclusive	10000run_2_5_292 Exclusive	0.02	0.90	1.80	1.30	2.89
10000run_2_5_292 Exclusive	Overlap	0.00	1.13	2.14	2.00	6.37
ad_gs_25 Exclusive	Overlap	0.03	89.61	54.37	176.57	24.56
Overlap	Exclusives	0.03	19.18	13.71	9.69	14.49

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_2_5_292 Exclusive	289	289	
ad_gs_25 Exclusive	22	22	
Overlap	3	3