Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_0_5_8595 Exclusive	ad_gs_25	7.41e-02	5.73e-01	2.46e-02	8.85e-06
ad_gs_25 Exclusive	10000run_0_5_8595	1.38e-06	3.53e-09	1.38e-218	4.12e-100
10000run_0_5_8595 Exclusive	ad_gs_25 Exclusive	3.91e-01	7.03e-01	1.40e-01	9.46e-03
ad_gs_25 Exclusive	10000run_0_5_8595 Exclusive	5.61e-07	5.54e-09	7.26e-212	2.39e-99
10000run_0_5_8595 Exclusive	Overlap	1.12e-01	7.47e-01	8.89e-02	1.38e-03
ad_gs_25 Exclusive	Overlap	3.29e-10	2.21e-11	2.07e-11	8.22e-11
Overlap	Exclusives	5.87e-36	5.73e-10	1.29e-241	2.85e-100



Evaluating how well 10000run_0_5_8595 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_0_5_8595 Exclusive	ad_gs_25	0.76	7.66	2.21	10.50	4.98
ad_gs_25 Exclusive	10000run_0_5_8595	0.57	2.06	21.44	1.74	46.17
10000run_0_5_8595 Exclusive	ad_gs_25 Exclusive	0.76	5.89	1.84	7.17	2.85
ad_gs_25 Exclusive	10000run_0_5_8595 Exclusive	0.57	1.99	18.97	1.47	50.57
10000run_0_5_8595 Exclusive	Overlap	0.76	7.65	1.32	10.20	3.16
ad_gs_25 Exclusive	Overlap	0.96	4.13	7.25	4.17	6.86
Overlap	Exclusives	0.57	2.44	23.59	1.86	45.72

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_0_5_8595 Exclusive	ad_gs_25	0.01	19.71	3.89	19.92	4.16
ad_gs_25 Exclusive	10000run_0_5_8595	0.49	2.10	31.15	2.14	40.15
10000run_0_5_8595 Exclusive	ad_gs_25 Exclusive	0.00	15.25	2.96	13.87	3.46
ad_gs_25 Exclusive	10000run_0_5_8595 Exclusive	0.48	1.78	28.04	1.72	38.07
10000run_0_5_8595 Exclusive	Overlap	0.00	17.86	1.40	22.42	2.82
ad_gs_25 Exclusive	Overlap	0.14	252.84	622.56	249.71	19.61
Overlap	Exclusives	0.49	2.35	28.66	2.20	36.77

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_0_5_8595 Exclusive	8561	8520	RBAK-RBAKDN;PAK6;CCDC7;RPS10-NUDT3;FXYD6-FXYD2;SHANK3;IQCJ-SCHIP1;CCDC188;MFRP;MYO15B;EPPIN-WFDC6;FAM47E-STBD1;RFPL2;TTC6;CYP3A7-CYP3A51P;TUBA4B;RNF103-CHMP3;UGT2A1;RFX1;TMED7-TICAM2;ANKHD1-EIF4EBP3;PRR36;TNFSF12-TNFSF13;STON1-GTF2A1L;C8orf89;GSG1L2;TFDP2;C3orf49;MSANTD3-TMEFF1;FAM205C;CROCC2;NPIPB6;CORO7-PAM16;MUC2;PRAMEF11;PTGES3L-AARSD1;C19orf84;ZNF559-ZNF177;RPL17-C18orf32;TVP23C-CDRT4;JMJD7-PLA2G4B
ad_gs_25 Exclusive	11	11	
Overlap	14	14