Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
10000run_1_5_2062 Exclusive	ad_gs_25	5.08e-01	4.83e-01	3.05e-02	5.32e-04
ad_gs_25 Exclusive	10000run_1_5_2062	2.29e-03	2.39e-02	4.36e-22	1.29e-13
10000run_1_5_2062 Exclusive	ad_gs_25 Exclusive	3.46e-01	3.92e-01	5.59e-02	3.77e-03
ad_gs_25 Exclusive	10000run_1_5_2062 Exclusive	6.30e-03	3.41e-02	5.92e-23	6.23e-13
10000run_1_5_2062 Exclusive	Overlap	8.45e-01	5.92e-01	2.10e-01	2.09e-02
ad_gs_25 Exclusive	Overlap	2.98e-14	2.98e-14	8.35e-13	5.11e-11
Overlap	Exclusives	2.64e-07	7.43e-03	1.24e-120	1.60e-14



Evaluating how well 10000run_1_5_2062 genes are linked to ad_gs_25 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_1_5_2062 Exclusive	ad_gs_25	0.74	1.59	2.12	1.64	4.34
ad_gs_25 Exclusive	10000run_1_5_2062	0.55	1.84	2.82	1.63	8.72
10000run_1_5_2062 Exclusive	ad_gs_25 Exclusive	0.72	2.04	2.27	1.57	3.08
ad_gs_25 Exclusive	10000run_1_5_2062 Exclusive	0.55	1.67	3.04	1.68	8.25
10000run_1_5_2062 Exclusive	Overlap	0.78	-0.57	-0.69	0.21	2.40
ad_gs_25 Exclusive	Overlap	1.00	3.69	3.78	3.43	4.02
Overlap	Exclusives	0.55	2.01	2.89	0.93	8.51

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
10000run_1_5_2062 Exclusive	ad_gs_25	0.00	1.62	2.43	1.96	1.59
ad_gs_25 Exclusive	10000run_1_5_2062	0.12	2.33	2.87	2.42	7.94
10000run_1_5_2062 Exclusive	ad_gs_25 Exclusive	0.00	2.29	3.15	1.68	2.93
ad_gs_25 Exclusive	10000run_1_5_2062 Exclusive	0.12	1.47	2.36	1.90	5.77
10000run_1_5_2062 Exclusive	Overlap	0.00	-0.13	-0.67	1.43	2.48
ad_gs_25 Exclusive	Overlap	0.08	171.15	196.02	102.42	57.53
Overlap	Exclusives	0.12	3.02	3.21	1.81	8.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
10000run_1_5_2062 Exclusive	2053	2042	RBAK-RBAKDN;RPL17-C18orf32;C3orf49;MFRP;UGT2A1;PTGES3L-AARSD1;C19orf84;STON1-GTF2A1L;CROCC2;PRAMEF11;FAM47E-STBD1
ad_gs_25 Exclusive	19	19	
Overlap	6	6